Title:
APPLICATION OF ISOQUINOLINE COMPOUND IN TUMOR TREATMENT
Document Type and Number:
WIPO Patent Application WO/2022/095972
Kind Code:
A1
Abstract:
The present invention relates to an application of an isoquinoline compound in tumor treatment. Specifically, the present invention provides a use of a compound of formula I, or an optical isomer or a racemate thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof used for the preparation of a composition or formulation for the prevention and/or treatment of a tumor. The compound of the present invention has significant and exceptional therapeutic effects on tumors with low or no expression of an NNMT gene, high expression of a DNA methylase, high expression of UHRF1, high methylation levels at an NNMT gene nucleotide site, and/or high methylation levels at a DNA CpG site in an NNMT gene region.
Inventors:
SHI YUFENG (CN)
MA WENJIANG (CN)
JIANG CIZHONG (CN)
WU CHANGQING (CN)
LIU YU'E (CN)
LIU WENJU (CN)
MA WENJIANG (CN)
JIANG CIZHONG (CN)
WU CHANGQING (CN)
LIU YU'E (CN)
LIU WENJU (CN)
Application Number:
PCT/CN2021/129066
Publication Date:
May 12, 2022
Filing Date:
November 05, 2021
Export Citation:
Assignee:
NANJING SHIJIANG MEDICINE TECH CO LTD (CN)
UNIV TONGJI (CN)
UNIV TONGJI (CN)
International Classes:
A61K31/4375; A61P35/00; C07D455/03; C12Q1/6886
Foreign References:
| CN112940044A | 2021-06-11 | |||
| CN101089245A | 2007-12-19 |
Other References:
CAO PENG, ZHANG ZI-WEI;LI YING;LENG DONG-JIN;LI XIAO-YAN: "Progress of Antibacterial Activity and Antibacterial Mechanism of Isoquinoline Alkaloids", CHINA JOURNAL OF CHINESE MATERIA MEDICA, vol. 41, no. 14, 31 July 2016 (2016-07-31), pages 2600 - 2606, XP055928806, DOI: 10.4268/cjcmm20161406
RAMSDEN DAVID B., ROSEMARY H WARING, DAVID J BARLOW, RICHARD B PARSONS: "Nicotinamide N-Methyltransferase in Health and Cancer", INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH, vol. 10, 30 June 2017 (2017-06-30), pages 1 - 19, XP055914471, DOI: 10.1177/1178646917691739
DATABASE REGISTRY 16 November 1984 (1984-11-16), ANONYMOUS : "Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-10-methoxy-9-propoxy-(9CI) (CA INDEX NAME)", XP055928801, retrieved from STN Database accession no. 26292-85-3
DATABASE REGISTRY 11 August 2004 (2004-08-11), ANONYMOUS : "Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-10-methoxy-9-(2-propenyloxy)-(9CI) (CA INDEX NAME)", XP055928800, retrieved from STN Database accession no. 725679-42-5
ZHANG YAN, ZHANG LIANG, ZHOU YIMING, ET AL : "Study on Pharmacological Action Mechanism of Berberine Chloride by Genome-wide Expression Profiling of Saccharomyces cerevisiae", CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE, vol. 23, no. 1, 31 December 2003 (2003-12-31), pages 48 - 53, XP055928796
"NCBI", Database accession no. 29128
"Uniprotkb/Swiss", Database accession no. Q96T88
RAMSDEN DAVID B., ROSEMARY H WARING, DAVID J BARLOW, RICHARD B PARSONS: "Nicotinamide N-Methyltransferase in Health and Cancer", INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH, vol. 10, 30 June 2017 (2017-06-30), pages 1 - 19, XP055914471, DOI: 10.1177/1178646917691739
DATABASE REGISTRY 16 November 1984 (1984-11-16), ANONYMOUS : "Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-10-methoxy-9-propoxy-(9CI) (CA INDEX NAME)", XP055928801, retrieved from STN Database accession no. 26292-85-3
DATABASE REGISTRY 11 August 2004 (2004-08-11), ANONYMOUS : "Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-10-methoxy-9-(2-propenyloxy)-(9CI) (CA INDEX NAME)", XP055928800, retrieved from STN Database accession no. 725679-42-5
ZHANG YAN, ZHANG LIANG, ZHOU YIMING, ET AL : "Study on Pharmacological Action Mechanism of Berberine Chloride by Genome-wide Expression Profiling of Saccharomyces cerevisiae", CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE, vol. 23, no. 1, 31 December 2003 (2003-12-31), pages 48 - 53, XP055928796
"NCBI", Database accession no. 29128
"Uniprotkb/Swiss", Database accession no. Q96T88
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
Download PDF:
Previous Patent: SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Next Patent: URATE OXIDASE PREPARATION AND USE THEREOF
Next Patent: URATE OXIDASE PREPARATION AND USE THEREOF