Title:
SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/095971
Kind Code:
A1
Abstract:
Provided are a spiro heterocyclic compound, a preparation method therefor and use thereof. The spiro heterocyclic compound is represented by formula I. The compound has inhibitory activity on RORγt, can effectively inhibit the RORγt protein receptor, thereby regulating the differentiation of Th17 cells, inhibiting the generation of IL-17, and then treating related autoimmune diseases mediated by RORγt.
Inventors:
WANG QIAN (CN)
ZHANG BINGBIN (CN)
SHI CHEN (CN)
SHU SIJIE (CN)
HUO GUOYONG (CN)
XIANG ZHIJUN (CN)
XIA GUANGXIN (CN)
WU GUOSHENG (CN)
LIANG TAO (CN)
ZHAO YONGXIN (CN)
LI LINGWEN (CN)
KE YING (CN)
ZHANG BINGBIN (CN)
SHI CHEN (CN)
SHU SIJIE (CN)
HUO GUOYONG (CN)
XIANG ZHIJUN (CN)
XIA GUANGXIN (CN)
WU GUOSHENG (CN)
LIANG TAO (CN)
ZHAO YONGXIN (CN)
LI LINGWEN (CN)
KE YING (CN)
Application Number:
PCT/CN2021/129049
Publication Date:
May 12, 2022
Filing Date:
November 05, 2021
Export Citation:
Assignee:
SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN)
International Classes:
C07D491/20; A61K31/5386; A61P17/00; A61P19/02
Domestic Patent References:
| WO2021086966A1 | 2021-05-06 | |||
| WO2013067248A1 | 2013-05-10 | |||
| WO2011140425A1 | 2011-11-10 | |||
| WO2008088692A2 | 2008-07-24 | |||
| WO2018075959A1 | 2018-04-26 |
Foreign References:
| CN101541809A | 2009-09-23 |
Other References:
DATABASE REGISTRY 29 January 2017 (2017-01-29), ANONYMOUS : "INDEX NAME NOT YET ASSIGNED ", XP055928455, retrieved from STN Database accession no. 2061265-80-1 (+ 2060468-39-3 2060468-28-0)
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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