Title:
APPLICATION OF LIPID VEHICLES AND USE FOR DRUG DELIVERY
Document Type and Number:
WIPO Patent Application WO2003015698
Kind Code:
A3
Abstract:
The present invention relates to compositions and methods for the administration of lipid-based vehicles to treat various disorders, including bladder inflammation, infection, dysfunction, and cancer. In various aspects, the compositions and methods of the invention are useful for prolonged delivery of drugs, e.g., antibiotics, pain treatments, and anticancer agents, to the bladder, genitourinary tract, gastrointestinal system, pulmonary system, and other organs or body systems. In particular, the present invention relates to liposome-based delivery of vanilloid compounds, such as resiniferatoxin, capsaicin, or tinyatoxin, and toxins, such as botulinum toxin, for the treatment of bladder conditions, including pain, inflammation, incontinence, and voiding dysfunction. Further related are methods of using these vehicles alone or in conjunction with antibodies, e.g., uroplakin antibodies, to improve duration of liposome attachment, and provide a long-term intravesical drug delivery platform. The present invention specifically relates to antibody-coated liposomes that are useful for targeting specific receptors for drug, peptide, polypeptide, or nucleic acid delivery. In one particular aspect, the present invention relates to liposomes coated with antibodies against nerve growth factor (NGF) receptor and containing NGF antisense nucleic acids, which are used as a treatment for neurogenic bladder dysfunction.
Inventors:
CHANCELLOR MICHAEL B (US)
FRASER MATTHEW O (US)
CHUANG YAO-CHI
DE GROAT WILLIAM C (US)
HUANG LEAF (US)
YOSHIMURA NAOKI (US)
FRASER MATTHEW O (US)
CHUANG YAO-CHI
DE GROAT WILLIAM C (US)
HUANG LEAF (US)
YOSHIMURA NAOKI (US)
Application Number:
PCT/US2002/025860
Publication Date:
July 10, 2003
Filing Date:
August 13, 2002
Export Citation:
Assignee:
UNIV PITTSBURGH (US)
CHANCELLOR MICHAEL B (US)
FRASER MATTHEW O (US)
CHUANG YAO-CHI
DE GROAT WILLIAM C (US)
HUANG LEAF (US)
YOSHIMURA NAOKI (US)
CHANCELLOR MICHAEL B (US)
FRASER MATTHEW O (US)
CHUANG YAO-CHI
DE GROAT WILLIAM C (US)
HUANG LEAF (US)
YOSHIMURA NAOKI (US)
International Classes:
A61K9/00; A61K9/127; A61K36/81; A61P29/00; A61P31/00; A61P35/00; (IPC1-7): A61K9/127; A61K9/107; A61K9/12
Foreign References:
| US6271211B1 | 2001-08-07 | |||
| US5763399A | 1998-06-09 | |||
| US4932936A | 1990-06-12 | |||
| US5298019A | 1994-03-29 | |||
| US6239267B1 | 2001-05-29 | |||
| US5698549A | 1997-12-16 | |||
| EP0036277A2 | 1981-09-23 |
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