Title:
INTERLEUKIN-2 MUTANTS WITH REDUCED TOXICITY
Document Type and Number:
WIPO Patent Application WO2003015697
Kind Code:
A3
Abstract:
Interleukin-2 (IL-2) mutants having reduced toxicity, which include full-length IL-2, truncated forms of IL-2 and forms IL-2 that are linked to another molecule are disclosed herein. Particular substitutions within IL-2, particularly within the permeability enhancing peptide region of IL-2 achieve substantial reduction of vasopermeability activity as compared to a wildtype form of the mutant IL-2. Invention IL-2 mutants can be used to stimulate the immune system of an animal and may be used in the treatment of various disorders and conditions.
Inventors:
EPSTEIN ALAN L (US)
HU PEISHENG (US)
HU PEISHENG (US)
Application Number:
PCT/US2002/025647
Publication Date:
September 02, 2004
Filing Date:
August 12, 2002
Export Citation:
Assignee:
UNIV SOUTHERN CALIFORNIA (US)
EPSTEIN ALAN L (US)
HU PEISHENG (US)
EPSTEIN ALAN L (US)
HU PEISHENG (US)
International Classes:
A61K38/00; A61K38/20; A61K39/39; A61K45/00; A61P31/18; A61P35/00; C12N15/09; A61P37/00; A61P37/04; C07K14/55; C07K16/18; C07K19/00; C12N15/12; C12P21/02; G01N33/50; (IPC1-7): A61K38/20; C07K14/55; C12N5/10; C12N15/12; C12N15/63; G01N33/53
Other References:
LEBERTHON ET AL: "Enhanced tumor uptake of macromolecules induced by a novel vasoactive interleukin 2 immunoconjugate", CANCER RESEARCH, vol. 51, 15 May 1991 (1991-05-15), pages 2694 - 2698, XP002069099
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