Title:
APPLICATION OF NELFINAVIR IN PREPARATION OF DRUG FOR PREVENTING AND TREATING NOVEL CORONAVIRUS PNEUMONIA
Document Type and Number:
WIPO Patent Application WO/2021/164689
Kind Code:
A1
Abstract:
The present invention relates to an application of nelfinavir in the preparation of a drug for preventing and treating novel coronavirus pneumonia. Specifically, the present invention relates to a use of nelfinavir and a pharmaceutical composition thereof as 2019 novel coronavirus (2019-nCov) 3CL proteinase inhibitors in the preparation of a drug for treating and/or preventing and alleviating related diseases caused by a 2019 novel coronavirus infection, such as a respiratory tract infection and pneumonia.
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Inventors:
XU ZHIJIAN (CN)
YAO HANGPING (CN)
XU YECHUN (CN)
WU NANPING (CN)
PENG CHENG (CN)
ZHENG MIN (CN)
LU XIANGYUN (CN)
SU HAIXIA (CN)
CHENG LINFANG (CN)
LIU FUMIN (CN)
WU HAIBO (CN)
JIN CHANGZHONG (CN)
WU ZHIGANG (CN)
SHEN JINGSHAN (CN)
ZHU WEILIANG (CN)
JIANG HUALIANG (CN)
LI LANJUAN (CN)
ZHENG YONGTANG (CN)
HAN JIANBAO (CN)
SONG TIANZHANG (CN)
FENG XIAOLI (CN)
TIAN RENRONG (CN)
LI CHUAN (CN)
YANG JUNLIN (CN)
GONG LIKUN (CN)
WU CHUNHUI (CN)
JIANG XIANGRUI (CN)
WANG ZHEN (CN)
YAO HANGPING (CN)
XU YECHUN (CN)
WU NANPING (CN)
PENG CHENG (CN)
ZHENG MIN (CN)
LU XIANGYUN (CN)
SU HAIXIA (CN)
CHENG LINFANG (CN)
LIU FUMIN (CN)
WU HAIBO (CN)
JIN CHANGZHONG (CN)
WU ZHIGANG (CN)
SHEN JINGSHAN (CN)
ZHU WEILIANG (CN)
JIANG HUALIANG (CN)
LI LANJUAN (CN)
ZHENG YONGTANG (CN)
HAN JIANBAO (CN)
SONG TIANZHANG (CN)
FENG XIAOLI (CN)
TIAN RENRONG (CN)
LI CHUAN (CN)
YANG JUNLIN (CN)
GONG LIKUN (CN)
WU CHUNHUI (CN)
JIANG XIANGRUI (CN)
WANG ZHEN (CN)
Application Number:
PCT/CN2021/076585
Publication Date:
August 26, 2021
Filing Date:
February 10, 2021
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV SCHOOL OF MEDICINE (CN)
HAINAN HAIYAO CO LTD (CN)
KUNMING INST ZOOLOGY CAS (CN)
THE FIRST AFFILIATED HOSPITAL ZHEJIANG UNIV SCHOOL OF MEDICINE (CN)
HAINAN HAIYAO CO LTD (CN)
KUNMING INST ZOOLOGY CAS (CN)
International Classes:
A61K45/06; A61K31/4706; A61K31/472; A61K31/4965; A61P11/00; A61P31/14
Other References:
XU ZHIJIAN, PENG CHENG, SHI YULONG, ZHU ZHENGDAN, MU KAIJIE, WANG XIAOYU, ZHU WEILIANG: "Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation", BIORXIV, 28 January 2020 (2020-01-28), pages 1 - 20, XP055803842, Retrieved from the Internet [retrieved on 20210511], DOI: 10.1101/2020.01.27.921627
DE CLERCQ ERIK: "Potential antivirals and antiviral strategies against SARS coronavirus infections", EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, FUTURE DRUGS, LONDON, GB, vol. 4, no. 2, 1 April 2006 (2006-04-01), GB, pages 291 - 302, XP055839286, ISSN: 1478-7210, DOI: 10.1586/14787210.4.2.291
LIU, Y.C. ; HUANG, V. ; CHAO, T.C. ; HSIAO, C.D. ; LIN, A. ; CHANG, M.F. ; CHOW, L.P.: "Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 333, no. 1, 22 July 2005 (2005-07-22), Amsterdam NL, pages 194 - 199, XP027218788, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2005.05.095
DE CLERCQ ERIK: "Potential antivirals and antiviral strategies against SARS coronavirus infections", EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, FUTURE DRUGS, LONDON, GB, vol. 4, no. 2, 1 April 2006 (2006-04-01), GB, pages 291 - 302, XP055839286, ISSN: 1478-7210, DOI: 10.1586/14787210.4.2.291
LIU, Y.C. ; HUANG, V. ; CHAO, T.C. ; HSIAO, C.D. ; LIN, A. ; CHANG, M.F. ; CHOW, L.P.: "Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 333, no. 1, 22 July 2005 (2005-07-22), Amsterdam NL, pages 194 - 199, XP027218788, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2005.05.095
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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