Title:
APPLICATION OF PRIMIDONE AS RIPK1 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/027240
Kind Code:
A1
Abstract:
An application of primidone as a RIPK1 inhibitor. Primidone can be used as a RIPK1 inhibitor to treat amyotrophic lateral sclerosis, multiple sclerosis, inflammatory bowel disease, Crohn's disease, ischemia-reperfusion injury, ischemic stroke, hemorrhagic stroke, psoriasis, etc.
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Inventors:
ZHA YUNHONG (CN)
HU XINQIAN (CN)
HE XIAOYAN (CN)
MOU YAN (CN)
ZHU GUOFENG (CN)
WEI JUN (CN)
ZHANG HONGBING (CN)
WANG JUN (CN)
ZHAO HAILONG (CN)
HUANG MING (CN)
YU YAJIE (CN)
LI MIN (CN)
AN DEHAI (CN)
WANG JIA (CN)
YOU XIAOLING (CN)
GU TANRONG (CN)
XIAO XIN (CN)
HU XINQIAN (CN)
HE XIAOYAN (CN)
MOU YAN (CN)
ZHU GUOFENG (CN)
WEI JUN (CN)
ZHANG HONGBING (CN)
WANG JUN (CN)
ZHAO HAILONG (CN)
HUANG MING (CN)
YU YAJIE (CN)
LI MIN (CN)
AN DEHAI (CN)
WANG JIA (CN)
YOU XIAOLING (CN)
GU TANRONG (CN)
XIAO XIN (CN)
Application Number:
PCT/CN2020/106856
Publication Date:
February 10, 2022
Filing Date:
August 04, 2020
Export Citation:
Assignee:
THE FIRST PEOPLE S HOSPITAL OF YICHANG THE PEOPLE S HOSPITAL OF CHINA THREE GORGES UNIV (CN)
International Classes:
A61K31/513; A61P1/00; A61P7/04; A61P9/10; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P29/00; A61P37/02
Foreign References:
| EP3789028A1 | 2021-03-10 | |||
| CN110759895A | 2020-02-07 |
Other References:
NADERI FERESHTEH ET AL: "The Efficacy of Primidone in Reducing Severe Cerebellar Tremors in Patients With Multiple Sclerosis", CLINICAL NEUROPHARMACOLOGY, vol. 35, no. 5, 1 September 2012 (2012-09-01), pages 224 - 226, XP002798321, DOI: 10.1097/WNF.0b013e31826249bb
MOERKE CAROLINE; JACO ISABEL; DEWITZ CHRISTIN; MüLLER TAMMO; JACOBSEN ANNETTE V.; GAUTHERON JéRéMIE; FRITSCH Jü: "The anticonvulsive Phenhydan®suppresses extrinsic cell death", CELL DEATH & DIFFERENTIATION, NATURE PUBLISHING GROUP, GB, vol. 26, no. 9, 15 November 2018 (2018-11-15), GB , pages 1631 - 1645, XP036854681, ISSN: 1350-9047, DOI: 10.1038/s41418-018-0232-2
GEOFFREY J MARKOWITZ , SHILPA D KADAM , DANI R SMITH , MICHAEL V JOHNSTON , ANNE M COMI: "Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice", EPILEPSY RESEARCH, ELSEVIER SCIENCE PUBLISHERS , AMSTERDAM, NL, vol. 94, no. 3, 9 April 2001 (2001-04-09), NL , pages 138 - 148, XP009529061, ISSN: 0920-1211, DOI: 10.1016/j.eplepsyres.2011.01.002
XU-XU DENG, SHAN-SHAN LI, FENG-YAN SUN: "Necrostatin-1 Prevents Necroptosis in Brains after Ischemic Stroke via Inhibition of RIPK1-Mediated RIPK3/MLKL Signaling", AGING AND DISEASE, BUCK INSTITUTE FOR AGE RESEARCH, US, vol. 10, no. 4, 1 January 2019 (2019-01-01), US , pages 807, XP055676565, ISSN: 2152-5250, DOI: 10.14336/AD.2018.0728
ALEXEI DEGTEREV, DIMITRY OFENGEIM, JUNYING YUAN: "Targeting RIPK1 for the treatment of human diseases", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, pages 201901179, XP055652870, ISSN: 0027-8424, DOI: 10.1073/pnas.1901179116
JUE HOU, JIE JU, ZILI ZHANG, CONG ZHAO, ZHANHUI LI, JIYUE ZHENG, TIAN SHENG, HONGJIAN ZHANG, LINKUN HU, XIAOLIANG YU, WEI ZHANG, Y: "Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis", CELL DEATH & DISEASE, vol. 10, no. 7, 1 July 2019 (2019-07-01), XP055676349, DOI: 10.1038/s41419-019-1735-6
MOERKE CAROLINE; JACO ISABEL; DEWITZ CHRISTIN; MüLLER TAMMO; JACOBSEN ANNETTE V.; GAUTHERON JéRéMIE; FRITSCH Jü: "The anticonvulsive Phenhydan®suppresses extrinsic cell death", CELL DEATH & DIFFERENTIATION, NATURE PUBLISHING GROUP, GB, vol. 26, no. 9, 15 November 2018 (2018-11-15), GB , pages 1631 - 1645, XP036854681, ISSN: 1350-9047, DOI: 10.1038/s41418-018-0232-2
GEOFFREY J MARKOWITZ , SHILPA D KADAM , DANI R SMITH , MICHAEL V JOHNSTON , ANNE M COMI: "Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice", EPILEPSY RESEARCH, ELSEVIER SCIENCE PUBLISHERS , AMSTERDAM, NL, vol. 94, no. 3, 9 April 2001 (2001-04-09), NL , pages 138 - 148, XP009529061, ISSN: 0920-1211, DOI: 10.1016/j.eplepsyres.2011.01.002
XU-XU DENG, SHAN-SHAN LI, FENG-YAN SUN: "Necrostatin-1 Prevents Necroptosis in Brains after Ischemic Stroke via Inhibition of RIPK1-Mediated RIPK3/MLKL Signaling", AGING AND DISEASE, BUCK INSTITUTE FOR AGE RESEARCH, US, vol. 10, no. 4, 1 January 2019 (2019-01-01), US , pages 807, XP055676565, ISSN: 2152-5250, DOI: 10.14336/AD.2018.0728
ALEXEI DEGTEREV, DIMITRY OFENGEIM, JUNYING YUAN: "Targeting RIPK1 for the treatment of human diseases", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, pages 201901179, XP055652870, ISSN: 0027-8424, DOI: 10.1073/pnas.1901179116
JUE HOU, JIE JU, ZILI ZHANG, CONG ZHAO, ZHANHUI LI, JIYUE ZHENG, TIAN SHENG, HONGJIAN ZHANG, LINKUN HU, XIAOLIANG YU, WEI ZHANG, Y: "Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis", CELL DEATH & DISEASE, vol. 10, no. 7, 1 July 2019 (2019-07-01), XP055676349, DOI: 10.1038/s41419-019-1735-6
Attorney, Agent or Firm:
NANJING CANLAN INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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