Title:
APPLICATION OF SESQUITERPENE LACTONE COMPOUND IN PREPARATION OF DRUGS FOR ALLEVIATING RADIOTHERAPY-INDUCED INJURIES
Document Type and Number:
WIPO Patent Application WO/2022/083632
Kind Code:
A1
Abstract:
An application of a Sesquiterpene lactone compound, and a stereoisomer, isotopic marker, solvate and polymorph thereof, or a pharmaceutically acceptable salt thereof in the preparation of drugs for alleviating radiotherapy-induced injuries. The Sesquiterpene lactone compound is applied to assist radiotherapy, can effectively alleviate the radiotherapy-induced injuries, achieves a protection effect on normal cell tissues of a human body, and has a broad medicinal value.
Inventors:
CHEN YUE (CN)
CAI DONGPO (CN)
BAO SHIQI (CN)
ZHANG XUEMEI (CN)
CHEN JING (CN)
GONG JIANMIAO (CN)
GUO JIANSHUANG (CN)
LI JING (CN)
CAI DONGPO (CN)
BAO SHIQI (CN)
ZHANG XUEMEI (CN)
CHEN JING (CN)
GONG JIANMIAO (CN)
GUO JIANSHUANG (CN)
LI JING (CN)
Application Number:
PCT/CN2021/124940
Publication Date:
April 28, 2022
Filing Date:
October 20, 2021
Export Citation:
Assignee:
ACCENDATECH (CN)
UNIV NANKAI (CN)
UNIV NANKAI (CN)
International Classes:
A61K31/365; A61P35/04; A61P39/00
Domestic Patent References:
| WO2010059245A2 | 2010-05-27 |
Foreign References:
| US20190314324A1 | 2019-10-17 | |||
| CN202011149717A | 2020-10-23 | |||
| CN202111084087A | 2021-09-14 |
Other References:
TONG LUQING, LI JIABO, LI QIUYING, WANG XUYA, MEDIKONDA RAVI, ZHAO TIANNA, LI TAO, MA HAIWEN, YI LI, LIU PEIDONG, XIE YANG, CHOI J: "ACT001 reduces the expression of PD-L1 by inhibiting the phosphorylation of STAT3 in glioblastoma", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 10, no. 13, 1 January 2020 (2020-01-01), AU , pages 5943 - 5956, XP055923377, ISSN: 1838-7640, DOI: 10.7150/thno.41498
MOREL KATHERINE L., ORMSBY REBECCA J., BEZAK EVA, SWEENEY CHRISTOPHER J., SYKES PAMELA J.: "Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo,", RADIATION RESEARCH, vol. 187, no. 5, 3 March 2017 (2017-03-03), US , pages 501 - 512, XP009535901, ISSN: 0033-7587, DOI: 10.1667/RR14710.1
ZHOU GUIJUAN, XU YAN, HE BING, MA RUNDONG, WANG YILIN, CHANG YUNQIAN, XIE YANGZHI, WU LIN, HUANG JIANGHUA, XIAO ZIJIAN: "Ionizing radiation modulates vascular endothelial growth factor expression through STAT3 signaling pathway in rat neonatal primary astrocyte cultures", BRAIN AND BEHAVIOR, vol. 10, no. 4, 1 April 2020 (2020-04-01), pages 1529 - 12, XP055923382, ISSN: 2162-3279, DOI: 10.1002/brb3.1529
XI XIAONAN, LIU NING, WANG QIANQIAN, CHU YAHUI, YIN ZHENG, DING YAHUI, LU YAXIN: "ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma", CELL DEATH & DISEASE, vol. 10, no. 10, 1 October 2019 (2019-10-01), pages 757, XP055923385, DOI: 10.1038/s41419-019-1986-2
DERASKA PETER V., O’LEARY COLIN, REAVIS HUNTER D., LABE SHELBY, DINH TRU-KHANG, LAZARO JEAN-BERNARD, SWEENEY CHRISTOPHER, D’ANDREA: "NF-κB inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair", CELL DEATH DISCOVERY, vol. 4, no. 1, 1 December 2018 (2018-12-01), pages 10, XP055923386, DOI: 10.1038/s41420-017-0008-3
MOREL KATHERINE L., ORMSBY REBECCA J., KLEBE SONJA, SWEENEY CHRISTOPHER J., SYKES PAMELA J.: "DMAPT is an effective radioprotector from long-term radiation-induced damage to normal mouse tissues in vivo,", RADIATION RESEARCH, vol. 192, no. 2, 16 May 2019 (2019-05-16), US , pages 231 - 139, XP009535900, ISSN: 0033-7587, DOI: 10.1667/RR15404.1
LICKLITER JASON D., JENNENS ROSS, LEMECH CHARLOTTE ROSE, KICHENADASSE GANESSAN, CAI DONGPO, SU STEVEN YUNG-CHANG: "Phase 1 dose-escalation study of ACT001 in patients with recurrent glioblastoma and other advanced solid tumors,", JOURNAL OF CLINICAL ONCOLOGY, vol. 39, no. 15 S, 28 May 2021 (2021-05-28), US , pages 2037 - 2037, XP009535899, ISSN: 0732-183X, DOI: 10.1200/JCO.2021.39.15_suppl.2037
MOREL KATHERINE L., ORMSBY REBECCA J., BEZAK EVA, SWEENEY CHRISTOPHER J., SYKES PAMELA J.: "Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo,", RADIATION RESEARCH, vol. 187, no. 5, 3 March 2017 (2017-03-03), US , pages 501 - 512, XP009535901, ISSN: 0033-7587, DOI: 10.1667/RR14710.1
ZHOU GUIJUAN, XU YAN, HE BING, MA RUNDONG, WANG YILIN, CHANG YUNQIAN, XIE YANGZHI, WU LIN, HUANG JIANGHUA, XIAO ZIJIAN: "Ionizing radiation modulates vascular endothelial growth factor expression through STAT3 signaling pathway in rat neonatal primary astrocyte cultures", BRAIN AND BEHAVIOR, vol. 10, no. 4, 1 April 2020 (2020-04-01), pages 1529 - 12, XP055923382, ISSN: 2162-3279, DOI: 10.1002/brb3.1529
XI XIAONAN, LIU NING, WANG QIANQIAN, CHU YAHUI, YIN ZHENG, DING YAHUI, LU YAXIN: "ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma", CELL DEATH & DISEASE, vol. 10, no. 10, 1 October 2019 (2019-10-01), pages 757, XP055923385, DOI: 10.1038/s41419-019-1986-2
DERASKA PETER V., O’LEARY COLIN, REAVIS HUNTER D., LABE SHELBY, DINH TRU-KHANG, LAZARO JEAN-BERNARD, SWEENEY CHRISTOPHER, D’ANDREA: "NF-κB inhibition by dimethylaminoparthenolide radiosensitizes non-small-cell lung carcinoma by blocking DNA double-strand break repair", CELL DEATH DISCOVERY, vol. 4, no. 1, 1 December 2018 (2018-12-01), pages 10, XP055923386, DOI: 10.1038/s41420-017-0008-3
MOREL KATHERINE L., ORMSBY REBECCA J., KLEBE SONJA, SWEENEY CHRISTOPHER J., SYKES PAMELA J.: "DMAPT is an effective radioprotector from long-term radiation-induced damage to normal mouse tissues in vivo,", RADIATION RESEARCH, vol. 192, no. 2, 16 May 2019 (2019-05-16), US , pages 231 - 139, XP009535900, ISSN: 0033-7587, DOI: 10.1667/RR15404.1
LICKLITER JASON D., JENNENS ROSS, LEMECH CHARLOTTE ROSE, KICHENADASSE GANESSAN, CAI DONGPO, SU STEVEN YUNG-CHANG: "Phase 1 dose-escalation study of ACT001 in patients with recurrent glioblastoma and other advanced solid tumors,", JOURNAL OF CLINICAL ONCOLOGY, vol. 39, no. 15 S, 28 May 2021 (2021-05-28), US , pages 2037 - 2037, XP009535899, ISSN: 0732-183X, DOI: 10.1200/JCO.2021.39.15_suppl.2037
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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