Title:
APPLICATIONS OF HPK1 KINASE INHIBITOR IN PREVENTING AND/OR TREATING ANIMAL PATHOGEN INFECTION
Document Type and Number:
WIPO Patent Application WO/2021/254118
Kind Code:
A1
Abstract:
Applications of an HPK1 kinase inhibitor in preventing and/or treating an animal pathogen infection. The HPK1 kinase inhibitor is a small molecule HPK1 kinase inhibitor, specifically, the compound of formula I or a pharmaceutically acceptable salt, a stereoisomer, an ester, a prodrug, a solvate, or a deuterated compound of same. The HPK1 kinase inhibitor effectively treats diseases (such as feline infectious peritonitis) caused by infection of animal pathogens (specifically viruses, such as coronaviruses), improves animal survival, and provides enhanced commercial value and application prospects in the field of animal antiviral (specifically viruses, such as coronaviruses) medicaments.
Inventors:
LIN XINGYU (CN)
LU TINGTING (CN)
LU TINGTING (CN)
Application Number:
PCT/CN2021/096276
Publication Date:
December 23, 2021
Filing Date:
May 27, 2021
Export Citation:
Assignee:
ZHUHAI YUFAN BIOTECHNOLOGIES CO LTD (CN)
International Classes:
A61K31/4427; A61P31/14; A61P31/16; A61P31/20; A61P31/22; C07D213/76; C07D241/20; C07D401/04; C07D401/14; C07D409/04; C07D417/04; C07D417/14
Domestic Patent References:
| WO2020255022A1 | 2020-12-24 | |||
| WO2019196937A1 | 2019-10-17 | |||
| WO2019221601A1 | 2019-11-21 | |||
| WO2019206049A1 | 2019-10-31 | |||
| WO2016188972A1 | 2016-12-01 | |||
| WO2019126505A1 | 2019-06-27 |
Other References:
KUMAR, A. RHODES, R. SPYCHALA, J. WILSON, W. BOYKIN, D. TIDWELL, R. DYKSTRA, C. HALL, J. JONES, S. SCHINAZI, R.: "Synthesis of dicationic diarylpyridines as nucleic-acid binding agents", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 30, no. 2, 1 January 1995 (1995-01-01), AMSTERDAM, NL , pages 99 - 106, XP004040124, ISSN: 0223-5234, DOI: 10.1016/0223-5234(96)88214-6
HERNANDEZ SAIRY, QING JING, THIBODEAU REBECCA HONG, DU XIANGNAN, PARK SUMMER, LEE HYANG-MI, XU MIN, OH SOYOUNG, NAVARRO ARMANDO, R: "The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function", CELL REPORTS, ELSEVIER INC, US, vol. 25, no. 1, 1 October 2018 (2018-10-01), US , pages 80 - 94, XP055881180, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.012
See also references of EP 4154881A4
HERNANDEZ SAIRY, QING JING, THIBODEAU REBECCA HONG, DU XIANGNAN, PARK SUMMER, LEE HYANG-MI, XU MIN, OH SOYOUNG, NAVARRO ARMANDO, R: "The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function", CELL REPORTS, ELSEVIER INC, US, vol. 25, no. 1, 1 October 2018 (2018-10-01), US , pages 80 - 94, XP055881180, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.09.012
See also references of EP 4154881A4
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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