Title:
APPLICATIONS OF MACELIGNAN IN PREPARING MEDICAMENT FOR PREVENTING AND TREATING NEURODEGENERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/103119
Kind Code:
A1
Abstract:
The present application relates to the technical field of medicine, and specifically relates to novel uses of macelignan, comprising applications in preparing a Tau protein oligomerization inhibitor, applications in preparing a Tau protein fibrosis inhibitor, applications in preparing a Tau protein hyperphosphorylation inhibitor, and applications in preparing a medicament for preventing and treating neurodegenerative diseases. Experiments show that macelignan effectively suppresses the formation of heparin-induced Tau protein fibers; by utilizing computer molecular docking, the way in which macelignan and Tau protein fiber monomers are bonded is confirmed; macelignan also reduces the level of phosphorylation of Tau protein at serine loci 396 and 404 in SH-SY5Y/Tau and HEK293/Tau cells; and, macelignan promotes the dephosphorylation effect of p-Tau protein by increasing the activity of PP2A.
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Inventors:
XU XU (CN)
CAI NAN (CN)
GU LIANG (CN)
LI MEITING (CN)
WU ZHIBING (CN)
YAO LIJUN (CN)
CAI NAN (CN)
GU LIANG (CN)
LI MEITING (CN)
WU ZHIBING (CN)
YAO LIJUN (CN)
Application Number:
PCT/CN2019/123883
Publication Date:
June 03, 2021
Filing Date:
December 09, 2019
Export Citation:
Assignee:
UNIV SHENZHEN (CN)
International Classes:
A61K31/36; A23L33/105; A61K36/185; A61P25/00; A61P25/14; A61P25/16; A61P25/28
Foreign References:
| CN101151029A | 2008-03-26 | |||
| CN101151029A | 2008-03-26 | |||
| CN110731959A | 2020-01-31 |
Attorney, Agent or Firm:
SHENZHEN TALENT PATENT SERVICE (CN)
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