Title:
APPROVAL PREDICTION DEVICE, APPROVAL PREDICTION METHOD, AND PROGRAM
Document Type and Number:
WIPO Patent Application WO/2014/054526
Kind Code:
A1
Abstract:
The present invention calculates a similarity centrality scale which is a centrality scale of proteins constituting a protein similarity network, calculates an interaction centrality scale which is a centrality scale of proteins constituting a protein interaction network, calculates a denial score which is the probability of a compound under verification being classified as a non-approved drug using a classifier which uses an approval attribute of each drug, the total value and average value of the similarity centrality scale for each drug target, and the total value and average value of the interaction centrality scale for each drug target as training data, and outputs the denial score.
Inventors:
DA SILVA LOPES TIAGO JOSE (JP)
KITANO HIROAKI (JP)
KAWAOKA YOSHIHIRO (JP)
KITANO HIROAKI (JP)
KAWAOKA YOSHIHIRO (JP)
Application Number:
PCT/JP2013/076248
Publication Date:
April 10, 2014
Filing Date:
September 27, 2013
Export Citation:
Assignee:
NAT INST JAPAN SCIENCE & TECHNOLOGY AGENCY (JP)
International Classes:
C40B30/02; G06F17/18; G06F17/30; G16B5/20; G16B35/00; G16H10/60; G06N20/00
Domestic Patent References:
| WO2005069188A1 | 2005-07-28 | |||
| WO2003077159A1 | 2003-09-18 |
Foreign References:
| JP2006146380A | 2006-06-08 |
Other References:
MICHAEL J. KEISER ET AL.: "Prediciting new molecular targets for known drugs", NATURE, vol. 462, November 2009 (2009-11-01), XP055257869
MONICA CAMPILLOS ET AL.: "Drug Target Identification Using Side-Effect Similarity", SCIENCE, vol. 321, July 2008 (2008-07-01), XP002534673
EUGEN LOUNKINE ET AL.: "Large-scale prediction and testing of drug activity on side-effect targets", NATURE, vol. 486, 21 June 2012 (2012-06-21), XP055257873
JUNJI SUZUKI ET AL.: "Knowledge Discovery from Protein-Protein-Interaction Data though Network Analysis", PROCEEDINGS OF THE 21ST ANNUAL CONFERENCE OF JSAI, June 2007 (2007-06-01), pages 1 - 2, XP008179454
ARMBRUSTER BN; ERNSBERGER P; IRWIN JJ; SHOICHET BK: "Relating protein pharmacology by ligand chemistry", NATURE BIOTECHNOLOGY, vol. 25, 2007, pages 197 - 206
CAMPILLOS M; KUHN M; GAVIN AC; JENSEN LJ; BORK P: "Drug Target Identification Using Side-Effect Similarity", SCIENCE, vol. 321, 2008, pages 263 - 266
KEISER MJ; SETOLA V; IRWIN JJ; LAGGNER C; ABBAS AI; HUFEISEN SJ; JENSEN NH; KUIJER MB; MATOS RC; TRAN TB: "Predicting new molecular targets for known drugs", NATURE, vol. 462, 2009, pages 175 - 181
YAMANISHI Y; ARAKI M; GUTTERIDGE A; HONDA W; KANEHISA M: "Prediction of drug target interaction networks from the integration of chemical and genomic spaces", BIOINFORMATICS, vol. 24, 2008, pages I232 - I240
LOUNKINE E; KEISER MJ; WHITEBREAD S; MIKHAILOV D; HAMON J; JENKINS JL; LAVAN P; WEBER E; DOAK AK; COTE S: "Large-scale prediction and testing of drug activity on side-effect targets", NATURE, vol. 486, 2012, pages 361 - 367
LIU Z; SHI Q; DING D; KELLY R; FANG H ET AL.: "Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps", PLOS COMPUT BIOL, vol. 7, no. 12, 2011, pages E1002310
See also references of EP 2905363A4
MONICA CAMPILLOS ET AL.: "Drug Target Identification Using Side-Effect Similarity", SCIENCE, vol. 321, July 2008 (2008-07-01), XP002534673
EUGEN LOUNKINE ET AL.: "Large-scale prediction and testing of drug activity on side-effect targets", NATURE, vol. 486, 21 June 2012 (2012-06-21), XP055257873
JUNJI SUZUKI ET AL.: "Knowledge Discovery from Protein-Protein-Interaction Data though Network Analysis", PROCEEDINGS OF THE 21ST ANNUAL CONFERENCE OF JSAI, June 2007 (2007-06-01), pages 1 - 2, XP008179454
ARMBRUSTER BN; ERNSBERGER P; IRWIN JJ; SHOICHET BK: "Relating protein pharmacology by ligand chemistry", NATURE BIOTECHNOLOGY, vol. 25, 2007, pages 197 - 206
CAMPILLOS M; KUHN M; GAVIN AC; JENSEN LJ; BORK P: "Drug Target Identification Using Side-Effect Similarity", SCIENCE, vol. 321, 2008, pages 263 - 266
KEISER MJ; SETOLA V; IRWIN JJ; LAGGNER C; ABBAS AI; HUFEISEN SJ; JENSEN NH; KUIJER MB; MATOS RC; TRAN TB: "Predicting new molecular targets for known drugs", NATURE, vol. 462, 2009, pages 175 - 181
YAMANISHI Y; ARAKI M; GUTTERIDGE A; HONDA W; KANEHISA M: "Prediction of drug target interaction networks from the integration of chemical and genomic spaces", BIOINFORMATICS, vol. 24, 2008, pages I232 - I240
LOUNKINE E; KEISER MJ; WHITEBREAD S; MIKHAILOV D; HAMON J; JENKINS JL; LAVAN P; WEBER E; DOAK AK; COTE S: "Large-scale prediction and testing of drug activity on side-effect targets", NATURE, vol. 486, 2012, pages 361 - 367
LIU Z; SHI Q; DING D; KELLY R; FANG H ET AL.: "Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps", PLOS COMPUT BIOL, vol. 7, no. 12, 2011, pages E1002310
See also references of EP 2905363A4
Attorney, Agent or Firm:
SAKAI, HIROAKI (JP)
Hiroaki Sakai (JP)
Hiroaki Sakai (JP)
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