AQUEOUS COMPOSITION HAVING IMPROVED HYDROPHILIC DRUG PENETRABILITY

Title:

AQUEOUS COMPOSITION HAVING IMPROVED HYDROPHILIC DRUG PENETRABILITY

Document Type and Number:

WIPO Patent Application WO/2012/108489

Kind Code:

A1

Abstract:

Provided is an aqueous composition containing a hydrophilic drug, wherein in order to improve the penetrability of the drug into the site of action of the drug so that a desired effect is exhibited at a low dose and safety when using the drug is improved, the aqueous composition contains the hydrophilic drug and a benzalkonium halide and has an osmotic pressure ratio of 0.5 or less. The aqueous composition preferably further contains a polyhydric alcohol. Further, the benzalkonium halide is preferably benzalkonium chloride.

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Inventors:

INAGAKI KOJI (JP)
HORIBE YOSHIHIDE (JP)
NAKADA YUICHIRO (JP)

Application Number:

PCT/JP2012/052932

Publication Date:

August 16, 2012

Filing Date:

February 09, 2012

Export Citation:

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Assignee:

SANTEN PHARMACEUTICAL CO LTD (JP)
INAGAKI KOJI (JP)
HORIBE YOSHIHIDE (JP)
NAKADA YUICHIRO (JP)

International Classes:

A61K47/18; A61K9/08; A61K31/7076; A61K47/10; A61P27/02; A61P27/06

Foreign References:

JP2005519978A	2005-07-07
JPH02503201A	1990-10-04
JP2010524933A	2010-07-22
JP2005206598A	2005-08-04
JP2005298448A	2005-10-27
JPH11130675A	1999-05-18
JPH10503470A	1998-03-31

Attorney, Agent or Firm:

Fukami Patent Office, p. c. (JP)
Patent business corporation Fukami patent firm (JP)

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Claims:

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