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Title:
AROMATIC ACETYLENE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/011574
Kind Code:
A1
Abstract:
Disclosed in the present invention are an aromatic acetylene derivative, a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of the aromatic acetylene derivative or the pharmaceutical composition thereof in medicines. Specifically, disclosed in the present invention are an aromatic acetylene derivative as represented by general formula (A-I), a preparation method therefor and a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, particularly an LPXC inhibitor, wherein the definition of each substituent in the general formula (A-I) is the same as that in the description.

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Inventors:
GUO YANGHUI (CN)
MENG LICHEN (CN)
LIAO WEIWEI (CN)
ZHANG HENG (CN)
WU CHENGFEI (CN)
CHEN YOUXI (CN)
YE CHENG (CN)
QIAN WENJIAN (CN)
CHEN LEI (CN)
WU ENGUO (CN)
Application Number:
PCT/CN2022/110173
Publication Date:
February 09, 2023
Filing Date:
August 04, 2022
Export Citation:
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Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
International Classes:
C07D413/06; A61K31/42; A61K31/4439; A61K31/506; A61P31/04; C07D413/14
Domestic Patent References:
WO2012162635A12012-11-29
WO2015085238A12015-06-11
WO2018216822A12018-11-29
WO2010100475A12010-09-10
WO2018216822A12018-11-29
WO2018208987A22018-11-15
WO2010012650A12010-02-04
WO2014142298A12014-09-18
WO2000034258A22000-06-15
WO2017093544A12017-06-08
WO2017221100A12017-12-28
Foreign References:
CN112996505A2021-06-18
CN106061977A2016-10-26
CN202110893728A2021-08-05
CN202210285860A2022-03-22
AP746472A
Other References:
EUROPEAN JOURNAL OF CHEMISTRY, vol. 9, no. 4, 2018, pages 317 - 321
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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