Title:
AROMATIC ACETYLENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/011573
Kind Code:
A1
Abstract:
The present invention relates to an aromatic acetylene derivative, a preparation method therefor, and a medical use of a pharmaceutical composition containing the derivative. Specifically, the present invention relates to an aromatic acetylene derivative represented by general formula (I), a preparation method therefor, a pharmaceutically acceptable salt thereof, and a use thereof as a therapeutic agent, especially an LPXC inhibitor, the definition of each substituent in general formula (I) being the same as the definition thereof in the description.
Inventors:
GUO YANGHUI (CN)
WANG XIN (CN)
CAO QI (CN)
MENG LICHEN (CN)
WU NUOYI (CN)
WU CHENGFEI (CN)
CHEN YOUXI (CN)
YE CHENG (CN)
QIAN WENJIAN (CN)
CHEN LEI (CN)
WANG XIN (CN)
CAO QI (CN)
MENG LICHEN (CN)
WU NUOYI (CN)
WU CHENGFEI (CN)
CHEN YOUXI (CN)
YE CHENG (CN)
QIAN WENJIAN (CN)
CHEN LEI (CN)
Application Number:
PCT/CN2022/110172
Publication Date:
February 09, 2023
Filing Date:
August 04, 2022
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
International Classes:
C07D413/04; A61K31/5377; A61P31/04
Domestic Patent References:
| WO2010017060A1 | 2010-02-11 | |||
| WO2020102572A1 | 2020-05-22 | |||
| WO2010100475A1 | 2010-09-10 |
Foreign References:
| US20180327365A1 | 2018-11-15 | |||
| CN101365677A | 2009-02-11 | |||
| CN101765585A | 2010-06-30 | |||
| CN113166077A | 2021-07-23 | |||
| CN101528711A | 2009-09-09 |
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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