Title:
AROMATIC ACETYLENE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067813
Kind Code:
A1
Abstract:
The present invention relates to an aromatic acetylene derivative, a preparation method therefor, and pharmaceutical use of a pharmaceutical composition comprising the derivative. Specifically, the present invention relates to an aromatic acetylene derivative represented by general formula (I), a preparation method therefor, a pharmaceutically acceptable salt thereof, and use thereof as a therapeutic agent, particularly as an LPXC inhibitor, wherein the definitions of the substituents in general formula (I) are the same as those in the specification.
Inventors:
HUANG XIANGUI (CN)
LIAO WEIWEI (CN)
WU CHENGFEI (CN)
YE CHENG (CN)
XU DAIWANG (CN)
XU XIAOJIE (CN)
ZHOU HOUJIANG (CN)
LIAO WEIWEI (CN)
WU CHENGFEI (CN)
YE CHENG (CN)
XU DAIWANG (CN)
XU XIAOJIE (CN)
ZHOU HOUJIANG (CN)
Application Number:
PCT/CN2023/122624
Publication Date:
April 04, 2024
Filing Date:
September 28, 2023
Export Citation:
Assignee:
ZHEJIANG HISUN PHARM CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
SHANGHAI ARYL PHARMTECH CO LTD (CN)
International Classes:
C07D413/14; A61K31/422; A61K31/454; A61P31/04; C07D413/06
Foreign References:
| CN112996505A | 2021-06-18 | |||
| CN107001295A | 2017-08-01 | |||
| CN101765585A | 2010-06-30 |
Other References:
USHIYAMA FUMIHITO ET AL.: "Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 30, 29 December 2020 (2020-12-29), XP086443796, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2020.115964
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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