Title:
AROMATIC AMINE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2008/044767
Kind Code:
A1
Abstract:
Disclosed is a novel SCD inhibitor. The SCD inhibitor comprises a compound represented
by the formula [I], a salt thereof, or a prodrug of the compound or the salt. wherein
the ring A represents an aromatic ring which may be substituted; the ring B represents
a ring which may be substituted; the ring C represents an aromatic ring which may
be substituted; R represents a hydrogen atom, a hydrocarbon group which may be
substituted, or a heterocyclic group which may be substituted; and X represents
a spacer having a main chain composed of 1 to 5 atoms.
Inventors:
TANIGUCHI TAKAHIKO (JP)
MIYATA KENICHI (JP)
KUBO OSAMU (JP)
MATSUI JUNJI (JP)
MIYATA KENICHI (JP)
KUBO OSAMU (JP)
MATSUI JUNJI (JP)
Application Number:
PCT/JP2007/069962
Publication Date:
April 17, 2008
Filing Date:
October 12, 2007
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
TANIGUCHI TAKAHIKO (JP)
MIYATA KENICHI (JP)
KUBO OSAMU (JP)
MATSUI JUNJI (JP)
TANIGUCHI TAKAHIKO (JP)
MIYATA KENICHI (JP)
KUBO OSAMU (JP)
MATSUI JUNJI (JP)
International Classes:
C07D213/75; A61K31/381; A61K31/415; A61K31/4155; A61K31/4162; A61K31/4196; A61K31/42; A61K31/422; A61K31/423; A61K31/425; A61K31/426; A61K31/437; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4436; A61K31/4439; A61K31/444; A61K31/454; A61K31/455; A61K31/50; A61K31/5377; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P7/02; A61P9/10; A61P43/00; C07D213/82; C07D231/12; C07D231/40; C07D237/20; C07D239/42; C07D241/22; C07D249/14; C07D261/14; C07D275/02; C07D277/20; C07D277/32; C07D277/46; C07D333/38; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D409/12; C07D413/12; C07D471/04; C07D495/04
Domestic Patent References:
| WO2006014580A1 | 2006-02-09 | |||
| WO2001007409A1 | 2001-02-01 | |||
| WO2007115930A1 | 2007-10-18 | |||
| WO2007115932A1 | 2007-10-18 | |||
| WO2006137350A1 | 2006-12-28 | |||
| WO2006123725A1 | 2006-11-23 | |||
| WO2006034312A1 | 2006-03-30 |
Foreign References:
| JPH11171856A | 1999-06-29 |
Other References:
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(2-chlorophenyl)methyl]-1H-pyrazolo-4-yl]-1-(phenoxymethyl)-", XP003022170, Database accession no. (2036147417)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(3-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]-1-[(4-fluorophenoxy)methyl]-", XP003022171, Database accession no. (2036147315)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[3,5-dimethyl-1-[(2-methylphenyl)methyl]-1H-pyrazol-4-yl]-1-[(2,5-dimethylphenoxy)methyl]-", XP003022172, Database accession no. (2036143045)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(2-chloro-4-fluorophenyl)methyl]-1H-pyrazol-4-yl]-1-(phenoxymethyl)-", XP003022173, Database accession no. (2036140766)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, 1-[(3-chlorophenoxy)methyl]-N-[1-(2-methylphenyl)methyl]-1H-pyrazol-4-yl]-", XP003022174, Database accession no. (2036140651)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(3-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]-1-(phenoxymethyl)-", XP003022175, Database accession no. (2036138602)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(2-fluorophenyl)methyl]-1H-pyrazol-4-yl]-1-[(2-methylphenoxy)methyl)-", XP003022176, Database accession no. (2036138556)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(4-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]-1-(phenoxymethyl)-", XP003022177, Database accession no. (2036138538)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(4-chlorophenyl)methyl]-1H-pyrazol-4-yl]-1-[(2-methylphenoxy)methyl]-", XP003022178, Database accession no. (2036136705)
DATABASE CHEMCATS [online] "1H-Pyrazol-3-carboxamide, 1-[(3,5-dimethylphenoxy)methyl]-N-[1-[(3-fluorophenyl)methyl]-1H-pyrazol-4-yl]-", XP003022179, Database accession no. (2036136653)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(2-chlorophenyl)methyl]-1H-pyrazol-4-yl]-1-[(4-fluorophenoxy)methyl]-", XP003022180, Database accession no. (2036136623)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(3-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]-1-[(4-fluorophenoxy)methyl]-", XP003022171, Database accession no. (2036147315)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[3,5-dimethyl-1-[(2-methylphenyl)methyl]-1H-pyrazol-4-yl]-1-[(2,5-dimethylphenoxy)methyl]-", XP003022172, Database accession no. (2036143045)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(2-chloro-4-fluorophenyl)methyl]-1H-pyrazol-4-yl]-1-(phenoxymethyl)-", XP003022173, Database accession no. (2036140766)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, 1-[(3-chlorophenoxy)methyl]-N-[1-(2-methylphenyl)methyl]-1H-pyrazol-4-yl]-", XP003022174, Database accession no. (2036140651)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(3-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]-1-(phenoxymethyl)-", XP003022175, Database accession no. (2036138602)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(2-fluorophenyl)methyl]-1H-pyrazol-4-yl]-1-[(2-methylphenoxy)methyl)-", XP003022176, Database accession no. (2036138556)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(4-chlorophenyl)methyl]-3,5-dimethyl-1H-pyrazol-4-yl]-1-(phenoxymethyl)-", XP003022177, Database accession no. (2036138538)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(4-chlorophenyl)methyl]-1H-pyrazol-4-yl]-1-[(2-methylphenoxy)methyl]-", XP003022178, Database accession no. (2036136705)
DATABASE CHEMCATS [online] "1H-Pyrazol-3-carboxamide, 1-[(3,5-dimethylphenoxy)methyl]-N-[1-[(3-fluorophenyl)methyl]-1H-pyrazol-4-yl]-", XP003022179, Database accession no. (2036136653)
DATABASE CHEMCATS [online] "1H-Pyrazole-3-carboxamide, N-[1-[(2-chlorophenyl)methyl]-1H-pyrazol-4-yl]-1-[(4-fluorophenoxy)methyl]-", XP003022180, Database accession no. (2036136623)
Attorney, Agent or Firm:
TAKASHIMA, Hajime (1-1 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka 44, JP)
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