Title:
AROMATIC COMPOUND, MIXTURE, MOLECULAR PROBE FOR HYPERPOLARIZATION, METABOLITE, DIAGNOSTIC AGENT, DERIVATIZATION AGENT, NAPHTHALENE DERIVATIVE, CATECHOL DERIVATIVE, AND COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/014325
Kind Code:
A1
Abstract:
An aromatic compound configured from a stable isotope, wherein two adjacent carbon atoms are 13C, the nuclear spin quantum number of the other atoms to which the two adjacent carbon atoms bond is 0, and a hydrogen atom that has a spin coupling constant and bonds with the 13 C nucleus via a carbon atom is substituted with a deuterium atom. In this aromatic compound, the relaxation time of the 13C nucleus excited by a DNP device is longer than in the past.
Inventors:
NEGORO MAKOTO (JP)
MIYANISHI KOICHIRO (JP)
KAGAWA AKINORI (JP)
MORITA YASUSHI (JP)
MURATA TSUYOSHI (JP)
TERAUCHI TSUTOMU (JP)
MIYANISHI KOICHIRO (JP)
KAGAWA AKINORI (JP)
MORITA YASUSHI (JP)
MURATA TSUYOSHI (JP)
TERAUCHI TSUTOMU (JP)
Application Number:
PCT/JP2023/024505
Publication Date:
January 18, 2024
Filing Date:
June 30, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
NAGOYA DENKI EDUCATIONAL FOUND (JP)
TAIYO NIPPON SANSO CORP (JP)
NAGOYA DENKI EDUCATIONAL FOUND (JP)
TAIYO NIPPON SANSO CORP (JP)
International Classes:
A61K31/045; C07C63/36; A61K31/136; A61K31/192; A61K31/198; A61K31/4035; A61K41/00; A61K49/10; A61P25/16; C07B59/00; C07C11/22; C07C33/34; C07C47/12; C07C211/58; C07C229/36; C07C255/04; C07D209/44
Foreign References:
| CN108911995A | 2018-11-30 | |||
| CN110256285A | 2019-09-20 |
Other References:
HILL-COUSINS JOSEPH T., POP IONUT-ALEXANDRU, PILEIO GIUSEPPE, STEVANATO GABRIELE, HÅKANSSON PÄR, ROY SOUMYA S., LEVITT MALCOLM H.,: "Synthesis of an Isotopically Labeled Naphthalene Derivative That Supports a Long-Lived Nuclear Singlet State", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 17, no. 9, 1 May 2015 (2015-05-01), US , pages 2150 - 2153, XP093128436, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.5b00744
TORIZAWA TAKUYA, ONO AKIRA MEI, TERAUCHI TSUTOMU, KAINOSHO MASATSUNE: "NMR Assignment Methods for the Aromatic Ring Resonances of Phenylalanine and Tyrosine Residues in Proteins", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 127, no. 36, 1 September 2005 (2005-09-01), pages 12620 - 12626, XP093128443, ISSN: 0002-7863, DOI: 10.1021/ja051386m
MITSUHIRO TAKEDA ; AKIRA M. ONO ; TSUTOMU TERAUCHI ; MASATSUNE KAINOSHO: "Application of SAIL phenylalanine and tyrosine with alternative isotope-labeling patterns for protein structure determination", JOURNAL OF BIOMOLECULAR NMR, KLUWER ACADEMIC PUBLISHERS, DO, vol. 46, no. 1, 7 August 2009 (2009-08-07), Do , pages 45 - 49, XP019770776, ISSN: 1573-5001
SCHORGHUBER JULIA; GEIST LEONHARD; PLATZER GERALD; FEICHTINGER MICHAEL; BISACCIA MARILENA; SCHEIBELBERGER LUKAS; WEBER FREDERIK; K: "Late metabolic precursors for selective aromatic residue labeling", JOURNAL OF BIOMOLECULAR NMR., ESCOM, LEIDEN., NL, vol. 71, no. 3, 28 May 2018 (2018-05-28), NL , pages 129 - 140, XP036558799, ISSN: 0925-2738, DOI: 10.1007/s10858-018-0188-z
TORIZAWA TAKUYA, ONO AKIRA MEI, TERAUCHI TSUTOMU, KAINOSHO MASATSUNE: "NMR Assignment Methods for the Aromatic Ring Resonances of Phenylalanine and Tyrosine Residues in Proteins", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, vol. 127, no. 36, 1 September 2005 (2005-09-01), pages 12620 - 12626, XP093128443, ISSN: 0002-7863, DOI: 10.1021/ja051386m
MITSUHIRO TAKEDA ; AKIRA M. ONO ; TSUTOMU TERAUCHI ; MASATSUNE KAINOSHO: "Application of SAIL phenylalanine and tyrosine with alternative isotope-labeling patterns for protein structure determination", JOURNAL OF BIOMOLECULAR NMR, KLUWER ACADEMIC PUBLISHERS, DO, vol. 46, no. 1, 7 August 2009 (2009-08-07), Do , pages 45 - 49, XP019770776, ISSN: 1573-5001
SCHORGHUBER JULIA; GEIST LEONHARD; PLATZER GERALD; FEICHTINGER MICHAEL; BISACCIA MARILENA; SCHEIBELBERGER LUKAS; WEBER FREDERIK; K: "Late metabolic precursors for selective aromatic residue labeling", JOURNAL OF BIOMOLECULAR NMR., ESCOM, LEIDEN., NL, vol. 71, no. 3, 28 May 2018 (2018-05-28), NL , pages 129 - 140, XP036558799, ISSN: 0925-2738, DOI: 10.1007/s10858-018-0188-z
Attorney, Agent or Firm:
SHIGA INTERNATIONAL PATENT OFFICE (JP)
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