Title:
AROMATIC COMPOUNDS WHICH ENHANCE NOTCH SIGNALING, FOR USE IN THERAPY
Document Type and Number:
WIPO Patent Application WO/2018/154118
Kind Code:
A3
Abstract:
The present invention comprises novel aromatic molecules, which can be used in the treatment of pathological conditions, such as cancer, skin diseases, muscle disorders, and immune system-related disorders such as disorders of the hematopoietic system including the hematologic system in human and veterinary medicine.
Inventors:
REINMÜLLER VIKTORIA (CH)
Application Number:
PCT/EP2018/054686
Publication Date:
December 06, 2018
Filing Date:
February 26, 2018
Export Citation:
Assignee:
XENIOPRO GMBH (DE)
International Classes:
A61P35/00; A61K31/192; A61K31/235; A61K31/4412; C07C63/06; C07D213/80
Domestic Patent References:
| WO1993024442A1 | 1993-12-09 | |||
| WO2009032249A1 | 2009-03-12 | |||
| WO2007022371A2 | 2007-02-22 | |||
| WO1993003012A1 | 1993-02-18 | |||
| WO2013093885A1 | 2013-06-27 | |||
| WO2017158190A1 | 2017-09-21 | |||
| WO2018096510A1 | 2018-05-31 |
Foreign References:
| US3113849A | 1963-12-10 | |||
| US2754286A | 1956-07-10 | |||
| EP1710233A1 | 2006-10-11 | |||
| US3940403A | 1976-02-24 | |||
| EP1145718A1 | 2001-10-17 | |||
| GB2380193A | 2003-04-02 | |||
| JP2011001294A | 2011-01-06 |
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V A ; GIORDANO ET AL: "Effect of Chain Length on Mesomorphfsm of Steroid Esters of 4-(4-Alkylphenyl-X)benzoic Acids with X = CO, 0, S, and CH2", JOURNAL OF PHYSICAL CHEMISTRY, 1 January 1973 (1973-01-01), pages 4730 - 4737, XP055470685, Retrieved from the Internet
GENZO ITO ET AL: "Notiz uber einige neue Diphenylather-aldehyde und deren Thiosemicarbazone.", PHARMACEUTICAL BULLETIN, vol. 5, no. 6, 1 January 1957 (1957-01-01), pages 619 - 621, XP055486381, ISSN: 0369-9471, DOI: 10.1248/cpb1953.5.619
AIYING GUAN ET AL: "Design, Synthesis, and Structure-Activity Relationship of New Pyrimidinamine Derivatives Containing an Aryloxy Pyridine Moiety", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 65, no. 6, 6 February 2017 (2017-02-06), US, pages 1272 - 1280, XP055485673, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.6b05580
P. M. HERGENROTHER ET AL: "Synthesis and thermal reaction of 2-[4-(4-ethynylphenoxy)phenylene]-3-phenylquinoxaline", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 13, no. 5, 1 October 1976 (1976-10-01), US, pages 993 - 999, XP055485851, ISSN: 0022-152X, DOI: 10.1002/jhet.5570130512
JIN HOU ET AL: "Evaluation of Novel N -(piperidine-4-yl)benzamide Derivatives as Potential Cell Cycle Inhibitors in HepG2 Cells", CHEMICAL BIOLOGY & DRUG DESIGN., vol. 86, no. 2, 1 August 2015 (2015-08-01), GB, pages 223 - 231, XP055485858, ISSN: 1747-0277, DOI: 10.1111/cbdd.12484
BUCK E ET AL: "Ullmann diaryl ether synthesis: rate aceleration by 2,2,6,6-tetramethylheptane-3,5-dione", ORGANIC LETTERS , 14(23), 6012-6015 CODEN: ORLEF7; ISSN: 1523-7052,, vol. 4, no. 9, 1 January 2002 (2002-01-01), pages 1623 - 1626, XP002403679, ISSN: 1523-7060, DOI: 10.1021/OL025839T
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 15 May 2008 (2008-05-15), XP002782250, accession no. 1020936-29-1 Database accession no. 1020936-29-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 27 July 2008 (2008-07-27), XP002782251, accession no. 1036524-79-4 Database accession no. 1036524-79-4
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 28 July 2008 (2008-07-28), XP002782252, accession no. 1036598-46-5 Database accession no. 1036598-46-5
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 17 August 2008 (2008-08-17), XP002782253, accession no. 1041517-52-5 Database accession no. 1041517-52-5
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 November 2013 (2013-11-25), XP002782254, accession no. 1480752-41-7 Database accession no. 1480752-41-7
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 February 2009 (2009-02-01), XP002782255, accession no. 1099130-61-6 Database accession no. 1099130-61-6
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 20 February 2014 (2014-02-20), XP002782256, accession no. 1550449-98-3 Database accession no. 1550449-98-3
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 5 December 2012 (2012-12-05), XP002782257, accession no. 1411168-77-8 Database accession no. 1411168-77-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 22 June 2016 (2016-06-22), XP002782258, accession no. 1937165-19-9 Database accession no. 1937165-19-9
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 15 November 2007 (2007-11-15), XP002782259, accession no. 953720-22-4 Database accession no. 953720-22-4
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 19 November 2007 (2007-11-19), XP002782260, accession no. 954564-77-3 Database accession no. 954564-77-3
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 February 2009 (2009-02-01), XP002782261, accession no. 1098368-66-1 Database accession no. 1098368-66-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 4 November 2013 (2013-11-04), XP002782262, accession no. 1468989-97-0 Database accession no. 1468989-97-0
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 29 December 2013 (2013-12-29), XP002782264, accession no. 1506498-75-4 Database accession no. 1506498-75-4
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 20 February 2014 (2014-02-20), XP002782265, accession no. 1550451-20-1 Database accession no. 1550451-20-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 May 2016 (2016-05-25), XP002782266, accession no. 1917642-56-8 Database accession no. 1917642-56-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 July 2016 (2016-07-03), XP002782267, accession no. 1944481-23-5 Database accession no. 1944481-23-5
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 July 2016 (2016-07-25), XP002782268, accession no. 1958884-22-4 Database accession no. 1958884-22-4
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 29 July 2016 (2016-07-29), XP002782269, accession no. 1962787-08-1 Database accession no. 1962787-08-1
YABUNAKA H ET AL: "Hybrid ubiquinone: novel inhibitor of mitochondrial complex I", BIOCHIMICA ET BIOPHYSICA ACTA. BIOENERGET, AMSTERDAM, NL, vol. 1556, no. 2-3, 2 December 2002 (2002-12-02), pages 106 - 112, XP004396758, ISSN: 0005-2728, DOI: 10.1016/S0005-2728(02)00341-9
MARTA P. CARRASCO ET AL: "Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 80, 1 June 2014 (2014-06-01), FR, pages 523 - 534, XP055513880, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.04.076
MARTA P. CARRASCO ET AL: "Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites", CHEMMEDCHEM, vol. 11, no. 19, 19 August 2016 (2016-08-19), DE, pages 2194 - 2204, XP055513882, ISSN: 1860-7179, DOI: 10.1002/cmdc.201600327
V A ; GIORDANO ET AL: "Effect of Chain Length on Mesomorphfsm of Steroid Esters of 4-(4-Alkylphenyl-X)benzoic Acids with X = CO, 0, S, and CH2", JOURNAL OF PHYSICAL CHEMISTRY, 1 January 1973 (1973-01-01), pages 4730 - 4737, XP055470685, Retrieved from the Internet
GENZO ITO ET AL: "Notiz uber einige neue Diphenylather-aldehyde und deren Thiosemicarbazone.", PHARMACEUTICAL BULLETIN, vol. 5, no. 6, 1 January 1957 (1957-01-01), pages 619 - 621, XP055486381, ISSN: 0369-9471, DOI: 10.1248/cpb1953.5.619
AIYING GUAN ET AL: "Design, Synthesis, and Structure-Activity Relationship of New Pyrimidinamine Derivatives Containing an Aryloxy Pyridine Moiety", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 65, no. 6, 6 February 2017 (2017-02-06), US, pages 1272 - 1280, XP055485673, ISSN: 0021-8561, DOI: 10.1021/acs.jafc.6b05580
P. M. HERGENROTHER ET AL: "Synthesis and thermal reaction of 2-[4-(4-ethynylphenoxy)phenylene]-3-phenylquinoxaline", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 13, no. 5, 1 October 1976 (1976-10-01), US, pages 993 - 999, XP055485851, ISSN: 0022-152X, DOI: 10.1002/jhet.5570130512
JIN HOU ET AL: "Evaluation of Novel N -(piperidine-4-yl)benzamide Derivatives as Potential Cell Cycle Inhibitors in HepG2 Cells", CHEMICAL BIOLOGY & DRUG DESIGN., vol. 86, no. 2, 1 August 2015 (2015-08-01), GB, pages 223 - 231, XP055485858, ISSN: 1747-0277, DOI: 10.1111/cbdd.12484
BUCK E ET AL: "Ullmann diaryl ether synthesis: rate aceleration by 2,2,6,6-tetramethylheptane-3,5-dione", ORGANIC LETTERS , 14(23), 6012-6015 CODEN: ORLEF7; ISSN: 1523-7052,, vol. 4, no. 9, 1 January 2002 (2002-01-01), pages 1623 - 1626, XP002403679, ISSN: 1523-7060, DOI: 10.1021/OL025839T
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 15 May 2008 (2008-05-15), XP002782250, accession no. 1020936-29-1 Database accession no. 1020936-29-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 27 July 2008 (2008-07-27), XP002782251, accession no. 1036524-79-4 Database accession no. 1036524-79-4
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 28 July 2008 (2008-07-28), XP002782252, accession no. 1036598-46-5 Database accession no. 1036598-46-5
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 17 August 2008 (2008-08-17), XP002782253, accession no. 1041517-52-5 Database accession no. 1041517-52-5
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 November 2013 (2013-11-25), XP002782254, accession no. 1480752-41-7 Database accession no. 1480752-41-7
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 February 2009 (2009-02-01), XP002782255, accession no. 1099130-61-6 Database accession no. 1099130-61-6
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 20 February 2014 (2014-02-20), XP002782256, accession no. 1550449-98-3 Database accession no. 1550449-98-3
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 5 December 2012 (2012-12-05), XP002782257, accession no. 1411168-77-8 Database accession no. 1411168-77-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 22 June 2016 (2016-06-22), XP002782258, accession no. 1937165-19-9 Database accession no. 1937165-19-9
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 15 November 2007 (2007-11-15), XP002782259, accession no. 953720-22-4 Database accession no. 953720-22-4
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 19 November 2007 (2007-11-19), XP002782260, accession no. 954564-77-3 Database accession no. 954564-77-3
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1 February 2009 (2009-02-01), XP002782261, accession no. 1098368-66-1 Database accession no. 1098368-66-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 4 November 2013 (2013-11-04), XP002782262, accession no. 1468989-97-0 Database accession no. 1468989-97-0
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 29 December 2013 (2013-12-29), XP002782264, accession no. 1506498-75-4 Database accession no. 1506498-75-4
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 20 February 2014 (2014-02-20), XP002782265, accession no. 1550451-20-1 Database accession no. 1550451-20-1
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 May 2016 (2016-05-25), XP002782266, accession no. 1917642-56-8 Database accession no. 1917642-56-8
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 3 July 2016 (2016-07-03), XP002782267, accession no. 1944481-23-5 Database accession no. 1944481-23-5
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 25 July 2016 (2016-07-25), XP002782268, accession no. 1958884-22-4 Database accession no. 1958884-22-4
DATABASE REGISTRY [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 29 July 2016 (2016-07-29), XP002782269, accession no. 1962787-08-1 Database accession no. 1962787-08-1
YABUNAKA H ET AL: "Hybrid ubiquinone: novel inhibitor of mitochondrial complex I", BIOCHIMICA ET BIOPHYSICA ACTA. BIOENERGET, AMSTERDAM, NL, vol. 1556, no. 2-3, 2 December 2002 (2002-12-02), pages 106 - 112, XP004396758, ISSN: 0005-2728, DOI: 10.1016/S0005-2728(02)00341-9
MARTA P. CARRASCO ET AL: "Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 80, 1 June 2014 (2014-06-01), FR, pages 523 - 534, XP055513880, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.04.076
MARTA P. CARRASCO ET AL: "Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites", CHEMMEDCHEM, vol. 11, no. 19, 19 August 2016 (2016-08-19), DE, pages 2194 - 2204, XP055513882, ISSN: 1860-7179, DOI: 10.1002/cmdc.201600327
Attorney, Agent or Firm:
WEICKMANN & WEICKMANN PARTMBB et al. (DE)
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