ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

Title:

ARYL AND HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

Document Type and Number:

WIPO Patent Application WO2005014533

Kind Code:

A3

Abstract:

This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway..

Inventors:

MJALLI ADNAN M M (US)
ANDREWS ROBERT C (US)
GUO XIAO-CHUAN (US)
CHRISTEN DANIEL PETER (US)
GOHIMMUKKULA DEVI REDDY (US)
HUANG GUOXIANG (US)
ROTHLEIN ROBERT (US)
TYAGI SAMEER (US)
YARAMASU TRIPURA (US)
BEHME CHRISTOPHER (US)

Application Number:

PCT/US2004/025463

Publication Date:

April 07, 2005

Filing Date:

August 06, 2004

Export Citation:

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Assignee:

TRANSTECH PHARMA INC (US)
MJALLI ADNAN M M (US)
ANDREWS ROBERT C (US)
GUO XIAO-CHUAN (US)
CHRISTEN DANIEL PETER (US)
GOHIMMUKKULA DEVI REDDY (US)
HUANG GUOXIANG (US)
ROTHLEIN ROBERT (US)
TYAGI SAMEER (US)
YARAMASU TRIPURA (US)
BEHME CHRISTOPHER (US)

International Classes:

A61P31/12; C07C233/87; C07C235/42; C07C235/52; C07C235/60; C07C235/66; C07C237/36; C07C237/42; C07C271/20; C07C311/08; C07C311/09; C07C311/21; C07C311/44; C07C317/32; C07C323/36; C07D295/155; (IPC1-7): C07C271/20; C07C233/29; C07C233/87; C07C235/42; C07C235/52; C07C235/60; C07C235/66; C07D207/09; C07D207/26; C07D211/66; C07D213/71; C07D217/02; C07D231/14; A61K31/166

Domestic Patent References:

WO2000076971A2	2000-12-21
WO2000035864A1	2000-06-22
WO2001021584A1	2001-03-29
WO2002018320A2	2002-03-07
WO2004046091A2	2004-06-03
WO2004084842A2	2004-10-07
WO1999026923A1	1999-06-03
WO1999036393A1	1999-07-22
WO2001010823A1	2001-02-15
WO2002062748A1	2002-08-15
WO2003033496A1	2003-04-24
WO2004014844A2	2004-02-19
WO1998037075A1	1998-08-27
WO2003007945A1	2003-01-30
WO2004080970A1	2004-09-23

Foreign References:

DE19928424A1	2000-12-28
FR2847251A1	2004-05-21
GB2354440A	2001-03-28
US20020016461A1	2002-02-07
US5750520A	1998-05-12
US5518735A	1996-05-21

Other References:

SIRCAR I ET AL: "Synthesis and SAR of N-benzoyl-L-Biphenylalanine derivatives: DISCOVERY OF TR-14035, A DUAL ALPHA4BETA7/ALPHA4BETA1 INTEGRIN ANTAGONIST", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 10, June 2002 (2002-06-01), pages 2051 - 2066, XP002250477, ISSN: 0968-0896
CASTANEDO G M ET AL: "Solid-Phase synthesis of dual alpha4beta1/alpha4beta7 Integrin antagonists: TWO SCAFFOLDS WITH OVERLAPPING PHARMACOPHORES", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 12, October 2002 (2002-10-01), pages 2913 - 2917, XP002250476, ISSN: 0960-894X
BURDICK D ET AL: "N-Benzoyl Amino Acids as LFA-1/ICAM Inhibitors 1: Amino Acid Structure-Activity Relationship", BIOORGANIC MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 6, 2003, pages 1015 - 118, XP002313197

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