PROCESS FOR PRODUCTION OF N-METHACRYLOYL-4-CYANO-3- TRIFLUOROMETHYLANILINE, METHOD FOR STABILIZATION OF THE SAME, AND PROCESS FOR PRODUCTION OF BICALUTAMIDE

Title:

PROCESS FOR PRODUCTION OF N-METHACRYLOYL-4-CYANO-3- TRIFLUOROMETHYLANILINE, METHOD FOR STABILIZATION OF THE SAME, AND PROCESS FOR PRODUCTION OF BICALUTAMIDE

Document Type and Number:

WIPO Patent Application WO/2005/014531

Kind Code:

A1

Abstract:

A process for the production of N-methacryloyl-4-cyano -3-trifluoromethylaniline which comprises reacting 4-cyano-3-trifluoromethylaniline with methacrylic acid or a reactive derivative thereof in the presence of a polymerization inhibitor; a process for the production of bicalutamide which comprises reacting 4-cyano-3-trifluoromethylaniline with methacrylic acid or a reactive derivative thereof in the presence of a polymerization inhibitor and reacting the obtained N-methacryloyl-4-cyano-3-trifluoromethylaniline with a peroxycarboxylic acid, 4-fluorothiophenol, and a peroxy- carboxylic acid successively; and a method for the stabilization of N-methacryloyl-4-cyano-3-trifluoromethylaniline which comprises incorporating a polymerization inhibitor into N-methacryloyl-4-cyano-3-trifluoromethylaniline.

Inventors:

SUGI KIYOSHI (JP)
SHINTAKU TETSUYA (JP)
KATSURA TADASHI (JP)
ITAYA NOBUSHIGE (JP)

Application Number:

PCT/JP2004/011800

Publication Date:

February 17, 2005

Filing Date:

August 11, 2004

Export Citation:

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Assignee:

SUMITOMO CHEMICAL CO (JP)
SUGI KIYOSHI (JP)
SHINTAKU TETSUYA (JP)
KATSURA TADASHI (JP)
ITAYA NOBUSHIGE (JP)

International Classes:

C07C253/30; C07C253/32; C07C255/60; C07C315/02; C07C317/46; C07C319/14; C07C323/60; (IPC1-7): C07C253/30; C07C253/32; C07C255/60; C07C315/02; C07C317/46; C07C319/14; C07C323/60

Domestic Patent References:

WO2002024638A1

2002-03-28

Foreign References:

JPS5826849A	1983-02-17
JPS5933250A	1984-02-23
US20030073742A1	2003-04-17

Other References:

TUCKER H. ET AL.: "Nonsteroidal antiandrogens. Synthesis and structure-activity relationship of 3-substituted derivatives of 2-hydroxypropionanilides", JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, 1988, pages 954 - 959, XP000605264

Attorney, Agent or Firm:

Enomoto, Masayuki c/o Sumitomo Chemical Intellectual Property Service (Limited 5-33, Kitahama 4-chome, Chuo-ku, Osaka-sh, Osaka 50, JP)

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