Title:
ARYL SUBSTITUTED PYRIMIDINES AND THE USE THEREOF
Document Type and Number:
WIPO Patent Application WO2003076414
Kind Code:
A3
Abstract:
This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aryl-substituted pyrimidine compounds of Formula (I): or a pharmaceutically acceptable salt, or solvate thereof, wherein A, R1, R2, R3 and R4 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
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Inventors:
GOEHRING R RICHARD
VICTORY SAM F
KYLE DONALD J
VICTORY SAM F
KYLE DONALD J
Application Number:
PCT/IB2003/001837
Publication Date:
December 24, 2003
Filing Date:
March 13, 2003
Export Citation:
Assignee:
EURO CELTIQUE SA (LU)
International Classes:
A61K31/506; A61K31/513; A61P3/10; A61P9/06; A61P9/10; A61P21/02; A61P23/00; A61P25/00; A61P25/02; A61P25/04; A61P25/20; A61P25/28; A61P27/16; A61P43/00; C07D239/00; C07D239/42; C07D239/46; (IPC1-7): C07D239/46; C07D239/32; A61K31/505; A61P25/00
Foreign References:
| DE1122533B | 1962-01-25 | |||
| EP0395328A2 | 1990-10-31 |
Other References:
TAKENORI NISHINO ET AL.: "THEREACTION MECHANISM OF 2-DIMETHOXYMETHYL-3-METHOXYPROPIONONITRILE WITH ACETAMIDINE.III.", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN., vol. 46, 1973, JAPAN PUBLICATIONS TRADING CO. TOKYO., JP, pages 253 - 9, XP002253453, ISSN: 0009-2673
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