Title:
OXO-AZABICYCLIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2003076417
Kind Code:
A3
Abstract:
A compound selected from those of formula (I) wherein: X1, X2, and X3, represent N or -CR3 in which R3 is as described in the description, G1 represents a group selected from those of formulae (i/a) and (i/b) in which R4, R5, and R6 are as defined in the description, G2 represents a group selected from carbon-carbon triple bond, -CH=C=CH-, C=O, C=S, S(O)n1 in which nl represents an integer from 0 to 2 inclusive, or a group of formula (i/c) in which Y1 represents O, S, -NH or -Nalkyl, and Y2 represents O, S, -NH or -Nalkyl, n is an integer from 0 to 6 inclusive, and m is an integer from 0 to 7 inclusive, Z1 represents -CR9R10,wherein R9 and R10 are as defined in the description, A represents a ring system, R1 represents a group selected from H, alkyl, alkenyl, alkynyl, optionally substituted and the group of formula (i/d) in which p, Z2, B, q and G3 are as defined in the description and optionally, its optical isomers, N-oxide, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are useful as specific inhibitors of type-13 matrix mettaloprotease.
Inventors:
GAUDILLIERE BERNARD (FR)
JACOBELLI HENRY (FR)
KOSTLAN CATHERINE (US)
LI JACK (US)
YUE WEN-SONG (US)
JACOBELLI HENRY (FR)
KOSTLAN CATHERINE (US)
LI JACK (US)
YUE WEN-SONG (US)
Application Number:
PCT/EP2003/002277
Publication Date:
November 13, 2003
Filing Date:
March 06, 2003
Export Citation:
Assignee:
WARNER LAMBERT CO (US)
GAUDILLIERE BERNARD (FR)
JACOBELLI HENRY (FR)
KOSTLAN CATHERINE (US)
LI JACK (US)
YUE WEN-SONG (US)
GAUDILLIERE BERNARD (FR)
JACOBELLI HENRY (FR)
KOSTLAN CATHERINE (US)
LI JACK (US)
YUE WEN-SONG (US)
International Classes:
A61K31/5025; A61K31/505; A61K31/517; A61K31/519; A61P1/02; A61P1/04; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P25/00; A61P29/00; A61P35/00; A61P43/00; C07D213/00; C07D221/00; C07D233/00; C07D239/00; C07D239/91; C07D257/00; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D403/06; C07D403/10; C07D471/04; C07D; (IPC1-7): C07D239/91; C07D471/04; A61K31/5025; A61K31/505; A61P29/00; C07D401/06; C07D401/10; C07D401/12
Domestic Patent References:
| WO1998026664A1 | 1998-06-25 | |||
| WO2002064572A1 | 2002-08-22 | |||
| WO2002064080A2 | 2002-08-22 |
Other References:
LIVERTON N J ET AL: "Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 5, 3 March 1998 (1998-03-03), pages 483 - 486, XP004136889, ISSN: 0960-894X
REITER L A ET AL: "Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, no. 2, 18 January 1999 (1999-01-18), pages 127 - 132, XP004152585, ISSN: 0960-894X
J.K. PADIA, H. CHILVERS, P.DAUM ET AL.: "Design and synthesis of novel nonpeptide CCK-B receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 7, 1997, pages 805 - 810, XP002222965
REITER L A ET AL: "Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, no. 2, 18 January 1999 (1999-01-18), pages 127 - 132, XP004152585, ISSN: 0960-894X
J.K. PADIA, H. CHILVERS, P.DAUM ET AL.: "Design and synthesis of novel nonpeptide CCK-B receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 7, no. 7, 1997, pages 805 - 810, XP002222965
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