Title:
ARYLALKYLAMINES AND PROCESS FOR PRODUCTION THEREOF
Document Type and Number:
WIPO Patent Application WO/2005/115975
Kind Code:
A1
Abstract:
Arylalkylamines represented by the general formula (I) or pharmacologically acceptable salts thereof; a process for the production of the compounds, use of the compounds as activator for Ca-sensitive receptors, i.e., as CaSR agonist, and medicinal compositions containing the compounds as the active ingredient wherein Ar is aryl or heteroaryl; R1 is a group selected from the group consisting of cyclic hydrocarbon groups and heterocyclic groups; n is an integer of 1 to 3; and X is a free single bond, -CH2-, -CO-, or the like.
Inventors:
MIYAZAKI HIROSHI
TSUBAKIMOTO JUNKO
YASUDA KOSUKE
TAKAMURO IWAO
SAKURAI OSAMU
YANAGIDA TETSUYA
HISADA YUTAKA
TSUBAKIMOTO JUNKO
YASUDA KOSUKE
TAKAMURO IWAO
SAKURAI OSAMU
YANAGIDA TETSUYA
HISADA YUTAKA
Application Number:
PCT/JP2005/009795
Publication Date:
December 08, 2005
Filing Date:
May 27, 2005
Export Citation:
Assignee:
TANABE SEIYAKU CO (JP)
MIYAZAKI HIROSHI
TSUBAKIMOTO JUNKO
YASUDA KOSUKE
TAKAMURO IWAO
SAKURAI OSAMU
YANAGIDA TETSUYA
HISADA YUTAKA
MIYAZAKI HIROSHI
TSUBAKIMOTO JUNKO
YASUDA KOSUKE
TAKAMURO IWAO
SAKURAI OSAMU
YANAGIDA TETSUYA
HISADA YUTAKA
International Classes:
A61K31/397; A61K31/40; A61K31/402; A61K31/4025; A61K31/404; A61K31/415; A61K31/4184; A61K31/4192; A61K31/427; A61K31/4439; A61K31/445; A61K31/451; A61K31/4545; A61K31/4709; A61K31/496; A61K31/497; A61K31/501; A61K31/502; A61K31/506; A61K31/5377; A61K31/5415; A61P5/20; A61P43/00; C07D205/04; C07D207/14; C07D207/16; C07D207/27; C07D207/327; C07D207/335; C07D207/34; C07D211/56; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D403/04; C07D403/06; C07D403/10; C07D405/12; C07D409/06; C07D409/12; C07D417/04; C07D417/06; C07D207/26; C07D207/32; (IPC1-7): C07D205/04; A61K31/397; A61K31/40; A61K31/402; A61K31/4025; A61K31/404; A61K31/415; A61K31/4184; A61K31/4192; A61K31/427; A61K31/4439; A61K31/445; A61K31/451; A61K31/4545; A61K31/4709; A61K31/496; A61K31/497; A61K31/501; A61K31/502; A61K31/506; A61K31/5377; A61K31/5415; A61P5/20; A61P43/00; C07D207/14; C07D207/327; C07D207/335; C07D207/34; C07D211/56; C07D401/04; C07D401/06
Domestic Patent References:
| WO2003099776A1 | 2003-12-04 | |||
| WO2003099814A1 | 2003-12-04 | |||
| WO1995011221A1 | 1995-04-27 | |||
| WO1997037967A1 | 1997-10-16 | |||
| WO1993004373A1 | 1993-03-04 | |||
| WO1994018959A1 | 1994-09-01 | |||
| WO1997041090A1 | 1997-11-06 |
Foreign References:
| JP2001226349A | 2001-08-21 | |||
| JPS6287565A | 1987-04-22 | |||
| JPH11221095A | 1999-08-17 | |||
| JP2001220356A | 2001-08-14 |
Other References:
See also references of EP 1757582A4
NEMETH ET AL., PROC. NATL. ACAD. SCI USA, vol. 95, 1998, pages 4040 - 4045
RACKE; NEMETH, J. PHYSIOL., vol. 468, 1993, pages 163 - 176
NEMETH ET AL., J. PHARMACOL. EXP. THER., vol. 308, 2004, pages 627 - 635
NEMETH ET AL., PROC. NATL. ACAD. SCI USA, vol. 95, 1998, pages 4040 - 4045
RACKE; NEMETH, J. PHYSIOL., vol. 468, 1993, pages 163 - 176
NEMETH ET AL., J. PHARMACOL. EXP. THER., vol. 308, 2004, pages 627 - 635
Attorney, Agent or Firm:
Tsukuni, Hajime (22-12 Toranomon 1-chome, Minato-k, Tokyo 01, JP)
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