Title:
ARYLPHENYLAMINO-AND ARYLPHENYLETHER-SULFIDE DERIVATIVES, USEFUL FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO2005105766
Kind Code:
A3
Abstract:
The present invention relates in part to compounds of formulas (I) and (III): and pharmaceutically-acceptable salts and prodrugs thereof. These compounds can be useful for treating diseases such as inflammatory and immune diseases. The present invention also relates to pharmaceutical compositions comprising these compounds, and to methods of inhibiting inflammation or suppressing immune response in a subject.
Inventors:
GUCKIAN KEVIN (US)
JACOBSON IRINA (US)
SCOTT DANIEL (US)
SOWELL C GREGORY (US)
JACOBSON IRINA (US)
SCOTT DANIEL (US)
SOWELL C GREGORY (US)
Application Number:
PCT/US2005/014802
Publication Date:
January 26, 2006
Filing Date:
April 28, 2005
Export Citation:
Assignee:
ICOS CORP (US)
BIOGEN IDEC INC (US)
GUCKIAN KEVIN (US)
JACOBSON IRINA (US)
SCOTT DANIEL (US)
SOWELL C GREGORY (US)
BIOGEN IDEC INC (US)
GUCKIAN KEVIN (US)
JACOBSON IRINA (US)
SCOTT DANIEL (US)
SOWELL C GREGORY (US)
International Classes:
A61K31/535; C07D211/26; C07D213/36; C07D213/38; C07D233/54; C07D295/185; C07D307/54; C07D309/04; (IPC1-7): C07D295/18; A61K31/535; A61P29/00; C07D211/26; C07D213/36; C07D233/54; C07D309/04
Domestic Patent References:
| WO2000059880A1 | 2000-10-12 | |||
| WO2000039081A2 | 2000-07-06 |
Other References:
LIU G ET AL: "Discovery of novel p-arylthio cinnamides as antagonists of leucocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 43, no. 21, 2000, pages 4025 - 4040, XP002279722, ISSN: 0022-2623
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