Title:
ARYLSULFATASE AND GLUCURONIDASE INHIBITOR, PREPARATION METHOD AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/253075
Kind Code:
A1
Abstract:
Disclosed is a method for preparing an arylsulfatase and glucuronidase inhibitor, comprising: adding NO or a chemical reactant capable of reacting to produce NO to a solvent to obtain a solution, such that the arylsulfatase and glucuronidase inhibitor is obtained. Also disclosed is an application of the arylsulfatase and glucuronidase inhibitor in the preparation of a drug for treating cancer.
Inventors:
LIU ZEHUA (CN)
ZHANG JUN (CN)
ZHONG SHUSHU (CN)
DANG ZHI (CN)
YIN HUA (CN)
ZHANG JUN (CN)
ZHONG SHUSHU (CN)
DANG ZHI (CN)
YIN HUA (CN)
Application Number:
PCT/CN2019/119053
Publication Date:
December 24, 2020
Filing Date:
November 18, 2019
Export Citation:
Assignee:
UNIV SOUTH CHINA TECH (CN)
International Classes:
A61P35/00; A61K9/08; A61K31/21; A61K31/34; A61K31/4422; C01B21/24
Foreign References:
| CN109432122A | 2019-03-08 | |||
| CN109432122A | 2019-03-08 | |||
| CN107823644A | 2018-03-23 |
Other References:
JIANG, HUI ET AL.: "Regulation of MMP-9/TIMP-1 expression in high concentration GTN treated tumor cells", LABELED IMMUNOASSAYS AND CLINICAL MEDICINE, vol. 17, no. 4, 31 August 2010 (2010-08-31), ISSN: 1006-1703, DOI: 20200304122936Y
WANG, DAN: "Observation on the immediate effects of intravenous injection of nifedipine on the severe hypertension", CHINESE JOURNAL OF PHARMACO EPIDEMIOLOGY, vol. 5, no. 4, 31 December 1996 (1996-12-31), ISSN: 1005-0698, DOI: 20200304123323Y
WANG, DAN: "Observation on the immediate effects of intravenous injection of nifedipine on the severe hypertension", CHINESE JOURNAL OF PHARMACO EPIDEMIOLOGY, vol. 5, no. 4, 31 December 1996 (1996-12-31), ISSN: 1005-0698, DOI: 20200304123605Y
YUAN, SHUYUN: "Medical preparation and use of nitric oxide", MEDICAL GASES ENGINEERING, vol. 2,, no. 1,, 31 March 2017 (2017-03-31), ISSN: 2096-2525, DOI: 20200304123849X
YUAN, SHUYUN: "Medical preparation and use of nitric oxide", MEDICAL GASES ENGINEERING, vol. 2,, no. 1,, 31 March 2017 (2017-03-31), ISSN: 2096-2525, DOI: 20200304123940Y
JIANG, HUI ET AL.: "Regulation of proliferation on lewis lung carcinoma cell by some drugs influences the nitric oxide level", ACADEMIC JOURNAL OF PLA POSTGRADUATE MEDICAL SCHOOL, vol. 26, no. 5, 31 October 2005 (2005-10-31), ISSN: 1005-1139, DOI: 20200304124537Y
WANG, DAN: "Observation on the immediate effects of intravenous injection of nifedipine on the severe hypertension", CHINESE JOURNAL OF PHARMACO EPIDEMIOLOGY, vol. 5, no. 4, 31 December 1996 (1996-12-31), ISSN: 1005-0698, DOI: 20200304123323Y
WANG, DAN: "Observation on the immediate effects of intravenous injection of nifedipine on the severe hypertension", CHINESE JOURNAL OF PHARMACO EPIDEMIOLOGY, vol. 5, no. 4, 31 December 1996 (1996-12-31), ISSN: 1005-0698, DOI: 20200304123605Y
YUAN, SHUYUN: "Medical preparation and use of nitric oxide", MEDICAL GASES ENGINEERING, vol. 2,, no. 1,, 31 March 2017 (2017-03-31), ISSN: 2096-2525, DOI: 20200304123849X
YUAN, SHUYUN: "Medical preparation and use of nitric oxide", MEDICAL GASES ENGINEERING, vol. 2,, no. 1,, 31 March 2017 (2017-03-31), ISSN: 2096-2525, DOI: 20200304123940Y
JIANG, HUI ET AL.: "Regulation of proliferation on lewis lung carcinoma cell by some drugs influences the nitric oxide level", ACADEMIC JOURNAL OF PLA POSTGRADUATE MEDICAL SCHOOL, vol. 26, no. 5, 31 October 2005 (2005-10-31), ISSN: 1005-1139, DOI: 20200304124537Y
Attorney, Agent or Firm:
GUANGZHOU HUAXUE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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