ASTHMA ASSOCIATED FACTORS AS TARGETS FOR TREATING ATOPIC ALLERGIES INCLUDING ASTHMA AND RELATED DISORDERS

WIPO Patent Application WO1999044620

A9

A new gene in the calcium-activated chloride channel family has been discovered that is induced by IL-9, thereby providing a therapeutic target in IL-9 mediated development of atopic allergy, asthma-related disorders and cystic fibrosis. A method for the identification and use of small molecule inhibitors of this gene and its products to treat these disorders has also been discovered. The invention also includes a method for diagnosing susceptibility to, and assessing treatment of atopic allergy, asthma-related disorders by measuring the level of gene expression in biologic samples using antibody specific for this protein.

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HOLROYD KENNETH J (US)
LEVITT ROY C (US)
MALOY W LEE (US)
LOUAHED JAMILA (US)
MCLANE MIKE (US)
NICOLAIDES NICHOLAS C (US)
ZHOU YUHONG (US)
DONG QU (US)

PCT/US1999/004703

May 17, 2001

March 03, 1999

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MAGAININ PHARMA (US)
HOLROYD KENNETH J (US)
LEVITT ROY C (US)
MALOY W LEE (US)
LOUAHED JAMILA (US)
MCLANE MIKE (US)
NICOLAIDES NICHOLAS C (US)
ZHOU YUHONG (US)
DONG QU (US)

G01N33/53; A61K31/7088; A61K38/00; A61K38/20; A61K39/395; A61K45/00; A61P1/00; A61P11/00; A61P11/06; A61P37/08; A61P43/00; C07H21/04; C07K14/705; C12N15/09; C12N15/12; C12P21/08; G01N33/68; (IPC1-7): A61K31/70; A61K39/395; C07H21/04; G01N33/53

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