Title:
ASYMMETRIC ARYL-ALKYL PERSULFATE COMPOUND, SYNTHESIS METHOD FOR SAME, AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/028050
Kind Code:
A1
Abstract:
Disclosed is an asymmetric aryl-alkyl persulfate compound as represented by formula (3) and a synthesis method therefor, in which an arylboronic acid of formula (1) and R2SSCOR3 of formula (2) serve as reaction raw materials and, under the effect of copper metal catalyst, react to produce the asymmetric aryl-alkyl persulfate compound. The present invention has mild reaction conditions, inexpensive and readily available raw materials, a simple reaction operation, high yield, and an inexpensive metal serving as the catalyst in the reaction, is economical, practical, and environmentally friendly, has a reaction substrate that can be prepared easily, and provides high reaction efficiency when the reaction is magnified. The asymmetric aryl-alkyl persulfate compound as represented by formula (3) prepared in the present invention is applicable in further synthesis of C-S bond-containing compounds such as benzyl(phenyl)sulfide and benzyl(4-methoxyphenyl)sulfide in a potential medicament. The present invention has broad application prospects and practical value.
More Like This:
Inventors:
JIANG XUEFENG (CN)
XIAO XIAO (CN)
FENG MINGHAO (CN)
XIAO XIAO (CN)
FENG MINGHAO (CN)
Application Number:
PCT/CN2016/103163
Publication Date:
February 15, 2018
Filing Date:
October 25, 2016
Export Citation:
Assignee:
UNIV EAST CHINA NORMAL (CN)
International Classes:
C07C319/22; C07C321/20; C07C321/28; C07C323/09; C07C323/20; C07C381/00; C07D307/64; C07D317/62; C07D493/04; C07H1/00; C07H13/06
Foreign References:
| CN104387303A | 2015-03-04 | |||
| CN106278965A | 2017-01-04 |
Other References:
KAWAMURA, S. ET AL.: "NMR and MS Studies of Miscellaneous Hydrodisulfides", ANNUAL REPORT OF THE RADIATION CENTER OF OSAKA PREFECTURE, vol. 20, 31 December 1979 (1979-12-31), pages 109
XIAO, XIAO ET AL.: "New Design of a Disulfurating Reagent: Facile and Straightforward Pathway to Unsymmetrical Disulfanes by Copper-Catalyzed Oxidative Cross-Coupling", ANGEWANDTE CHEMIE , INTERNATIONAL EDITION, vol. 55, no. 45, 11 August 2016 (2016-08-11), pages 14121 - 14125, XP055461081
TANIMOTO, S. ET AL.: "Base-induced Cleavage of Sulfur-Sulfur Bond in Several Disulfides Having a -Hydrogens", BULLETIN OF THE INSTITUTE FOR CHEMICAL RESEARCH, vol. 68, no. 3, 31 October 1990 (1990-10-31), pages 193 - 198, XP055461087
AYODELE, E.T. ET AL.: "Synthesis and fungicidal activity of acetyl substituted benzyl disulfides", BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, vol. 17, no. 1, 31 December 2003 (2003-12-31), pages 54, XP055461102
XIAO, XIAO ET AL.: "New Design of a Disulfurating Reagent: Facile and Straightforward Pathway to Unsymmetrical Disulfanes by Copper-Catalyzed Oxidative Cross-Coupling", ANGEWANDTE CHEMIE , INTERNATIONAL EDITION, vol. 55, no. 45, 11 August 2016 (2016-08-11), pages 14121 - 14125, XP055461081
TANIMOTO, S. ET AL.: "Base-induced Cleavage of Sulfur-Sulfur Bond in Several Disulfides Having a -Hydrogens", BULLETIN OF THE INSTITUTE FOR CHEMICAL RESEARCH, vol. 68, no. 3, 31 October 1990 (1990-10-31), pages 193 - 198, XP055461087
AYODELE, E.T. ET AL.: "Synthesis and fungicidal activity of acetyl substituted benzyl disulfides", BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, vol. 17, no. 1, 31 December 2003 (2003-12-31), pages 54, XP055461102
Attorney, Agent or Firm:
MSJ LAW OFFICE (CN)
Download PDF: