ASYMMETRIC UREA COMPOUND AND PROCESS FOR PRODUCING ASYMMETRIC COMPOUND BY ASYMMETRIC CONJUGATE ADDITION REACTION WITH THE SAME AS CATALYST

WIPO Patent Application WO/2005/000803

A2

A process for producing an asymmetric compound (IV), characterized by causing a compound (II) to add a nucleophilic reagent (III) through conjugate addition in the presence of an asymmetric urea compound (I). Also provided is a nonmetallic asymmetric catalyst capable of realizing asymmetric conjugate addition reaction which attain high yield and are highly stereoselective. The process is an advantageous process for producing an asymmetric compound by an asymmetric conjugate addition reaction in which the catalyst is used. [In the formulae, X represents oxygen or sulfur; C*, C**, and C*** each indicates asymmetric carbon; R¹, R², R⁴, R⁵, R⁸, R⁹, and R¹⁰ each represents optionally substituted lower alkyl, etc., provided that, for example, R⁴ and R⁵ may be bonded to each other to form an optionally substituted homocycle, etc.; R³ represents optionally substituted aryl, etc.; R⁶ and R⁷ each represents hydrogen, etc.; Nu represents -CR¹⁶(COR¹⁷)(COR¹⁸) (wherein R¹⁶, R¹⁷, and R¹⁸ each represents optionally substituted lower alkyl, etc.), etc.; and EWG represents an electron-withdrawing group.]

TAKEMOTO YOSHIJI (JP)

PCT/JP2004/009350

January 06, 2005

June 25, 2004

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SUMITOMO CHEMICAL CO (JP)
TAKEMOTO YOSHIJI (JP)

C07C201/12; C07C205/51; C07C205/53; C07C205/55; C07C231/10; C07C235/78; C07C269/06; C07C275/30; C07C335/16; C07C335/18; C07D209/08; C07D209/56; C07C271/22; C07D; (IPC1-7): C07D/

WO2003045937A1

2003-06-05

None
See also references of EP 1640361A4

Takashima, Hajime (1-1 Fushimimachi 4-chome, Chuo-k, Osaka-shi Osaka 44, JP)

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