Title:
ATP-PRT VARIANT WITH REDUCED FEEDBACK INHIBITION BY HISTIDINE, AND HISTIDINE-PRODUCING STRAIN EXPRESSING SAME
Document Type and Number:
WIPO Patent Application WO/2022/145586
Kind Code:
A1
Abstract:
The present invention relates to an E. coli hisG-derived ATP-phosphoribosyltransferase variant with reduced feedback inhibition by histidine, and a strain expressing same, the present invention maintaining activity even in a high concentration of histidine and thus enabling increased histidine production.
Inventors:
HAN JONG YUN (KR)
YANG CHEL MIN (KR)
KIM YONG SOO (KR)
JO YOUNG IL (KR)
YANG CHEL MIN (KR)
KIM YONG SOO (KR)
JO YOUNG IL (KR)
Application Number:
PCT/KR2021/005241
Publication Date:
July 07, 2022
Filing Date:
April 26, 2021
Export Citation:
Assignee:
DAESANG CORP (KR)
International Classes:
C12N9/10; C12N15/70; C12P13/24
Foreign References:
| US7300786B2 | 2007-11-27 | |||
| KR101904666B1 | 2018-11-29 | |||
| KR20170098205A | 2017-08-29 |
Other References:
DOROSHENKO V. G.; LOBANOV A. O.; FEDORINA E. A.: "The directed modification ofEscherichia coliMG1655 to obtain histidine-producing mutants", APPLIED BIOCHEMISTRY AND MICROBIOLOGY, NEW YORK, NY, US, vol. 49, no. 2, 26 February 2013 (2013-02-26), US , pages 130 - 135, XP035340162, ISSN: 0003-6838, DOI: 10.1134/S0003683813020026
DATABASE PROTEIN 7 June 2013 (2013-06-07), ANONYMOUS : "ATP phosphoribosyltransferase, partial [Escherichia coli MS 196-1]", XP055947101, retrieved from GENBANK Database accession no. EFI90688
MALYKH EVGENIYA A., BUTOV IVAN A., RAVCHEEVA ANNA B., KRYLOV ALEXANDER A., MASHKO SERGEY V., STOYNOVA NATALIYA V.: "Specific features of l-histidine production by Escherichia coli concerned with feedback control of AICAR formation and inorganic phosphate/metal transport", MICROBIAL CELL FACTORIES, vol. 17, 1 December 2018 (2018-12-01), pages 1 - 15, XP055918153, DOI: 10.1186/s12934-018-0890-2
VAN DER REST ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 52, 1999, pages 541 - 545
WARNER ET AL., PNAS, vol. 6, 2000, pages 6640 - 6645
MICROB CELL FACT, vol. 17, March 2018 (2018-03-01), pages 42
DATABASE PROTEIN 7 June 2013 (2013-06-07), ANONYMOUS : "ATP phosphoribosyltransferase, partial [Escherichia coli MS 196-1]", XP055947101, retrieved from GENBANK Database accession no. EFI90688
MALYKH EVGENIYA A., BUTOV IVAN A., RAVCHEEVA ANNA B., KRYLOV ALEXANDER A., MASHKO SERGEY V., STOYNOVA NATALIYA V.: "Specific features of l-histidine production by Escherichia coli concerned with feedback control of AICAR formation and inorganic phosphate/metal transport", MICROBIAL CELL FACTORIES, vol. 17, 1 December 2018 (2018-12-01), pages 1 - 15, XP055918153, DOI: 10.1186/s12934-018-0890-2
VAN DER REST ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 52, 1999, pages 541 - 545
WARNER ET AL., PNAS, vol. 6, 2000, pages 6640 - 6645
MICROB CELL FACT, vol. 17, March 2018 (2018-03-01), pages 42
Attorney, Agent or Firm:
PCR INTELLECTUAL PROPERTY LAW FIRM (KR)
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