Title:
ATTENUATED CHICKEN-POX VIRUS OKA STRAIN GENE 62 AND METHOD FOR IDENTIFYING VIRUS STRAIN FOR ATTENUATED LIVE CHICKEN-POX VACCINE BY USING THE GENE
Document Type and Number:
WIPO Patent Application WO/2000/050603
Kind Code:
A1
Abstract:
An attenuated chicken-pox virus Oka strain gene 62 having the base sequence represented by SEQ ID NO: 1 with at least the base substitutions (a) to (d) as specified below; (a) substitution of A at the 2110-position to G; (b) substitution of A at the 3100-position to G; (c) substitution of T at the 3818-position to G; and (d) substitution of A at the 4006-position to G; and a method for identifying the attenuated chicken-pox virus Oka strain and an attenuated chicken-pox virus strain acceptable as a virus strain for attenuated live chicken-pox vaccine.
Inventors:
GOMI YASUYUKI (JP)
IMAGAWA TADASHI (JP)
OSAME JUICHIRO (JP)
TAKAHASHI TOSHIAKI (JP)
YAMANISHI KOICHI (JP)
IMAGAWA TADASHI (JP)
OSAME JUICHIRO (JP)
TAKAHASHI TOSHIAKI (JP)
YAMANISHI KOICHI (JP)
Application Number:
PCT/JP1999/005476
Publication Date:
August 31, 2000
Filing Date:
October 05, 1999
Export Citation:
Assignee:
UNIV OSAKA RES FOUND (JP)
GOMI YASUYUKI (JP)
IMAGAWA TADASHI (JP)
OSAME JUICHIRO (JP)
TAKAHASHI TOSHIAKI (JP)
YAMANISHI KOICHI (JP)
GOMI YASUYUKI (JP)
IMAGAWA TADASHI (JP)
OSAME JUICHIRO (JP)
TAKAHASHI TOSHIAKI (JP)
YAMANISHI KOICHI (JP)
International Classes:
C07K14/04; C12N7/04; C12N15/38; C12P21/08; C12Q1/70; (IPC1-7): C12N15/38; A61K39/25; C07K14/04; C07K16/08; C12N5/06; C12N7/08; C12P21/08; C12Q1/68; C12Q1/70
Domestic Patent References:
| WO1997043420A1 | 1997-11-20 |
Foreign References:
| EP0510996A1 | 1992-10-28 | |||
| US3985615A | 1976-10-12 |
Other References:
FORGHANI B. ET AL.: "Monoclonal antibody to immediate early protein encoded by varicella-zoster virus gene 62", VIRUS RES.,, vol. 16, no. 2, 1990, pages 195 - 210, XP002925240
DAVISON A.J. ET AL.: "The complete DNA sequence of varicella-zoster virus", J. GEN. VIROL.,, vol. 67, no. 9, 1986, pages 1759 - 1816, XP002925241
See also references of EP 1074624A4
DAVISON A.J. ET AL.: "The complete DNA sequence of varicella-zoster virus", J. GEN. VIROL.,, vol. 67, no. 9, 1986, pages 1759 - 1816, XP002925241
See also references of EP 1074624A4
Attorney, Agent or Firm:
Nishizawa, Toshio (Udagawa-cho Shibuya-ku Tokyo, JP)
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