Title:
AZIDO DERIVATIVES OF CYCLOPENTANE HEPTANOIC OR HEPTENOIC ACID
Document Type and Number:
WIPO Patent Application WO1994008586
Kind Code:
A3
Abstract:
The present invention provides novel 2-aliphatic or arylaliphatic cyclopentane heptanoic and heptenoic acid derivatives including at least one azido substituent. In particular 2-aliphatic or arylaliphatic cyclopentane heptenyloic and cyclopentane heptanoic acids and esters thereof, substituted at the 3 and/or 5 position of the cyclopentane ring with radicals selected from the group consisting of hydroxy, azido and mixtures thereof, are disclosed. These azido compounds are useful as ocular hypotensives and are intermediates for the preparation of other compounds useful as ocular hypotensives.
Inventors:
CHAN, MING, FAI
Application Number:
PCT/US1993/009769
Publication Date:
May 26, 1994
Filing Date:
October 13, 1993
Export Citation:
Assignee:
ALLERGAN, INC.
International Classes:
A61K31/557; C07C405/00; (IPC1-7): A61K31/557
Foreign References:
| US4097489A | 1978-06-27 | |||
| US3935241A | 1976-01-27 | |||
| EP0093380A2 | 1983-11-09 |
Other References:
G. L. BUNDY ET AL.: "THE SYNTHESIS OF NITROGEN-CONTAINING PROSTACYCLIN ANALOGS.", TETRAHEDRON LETTERS, vol. 16, 1978, OXFORD GB, pages 1371 - 1374, XP000957084, DOI: doi:10.1016/S0040-4039(01)94548-4
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