BENZIMIDAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS

WIPO Patent Application WO2004101553

B1

The present invention relates to compounds of the formula (I), wherein R<0,>, R<1> , R<2>, Q, V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

NAZARE MARC (DE)
WAGNER MICHAEL (DE)
WEHNER VOLKMAR (DE)
MATTER HANS (DE)
URMANN MATTHIAS (DE)
RITTER KURT (DE)

PCT/EP2004/004750

March 03, 2005

May 05, 2004

Click for automatic bibliography generation  

AVENTIS PHARMA GMBH (DE)
NAZARE MARC (DE)
WAGNER MICHAEL (DE)
WEHNER VOLKMAR (DE)
MATTER HANS (DE)
URMANN MATTHIAS (DE)
RITTER KURT (DE)

A61P7/02; C07D235/24; C07D401/12; C07D401/14; C07D409/14; C07D413/12; C07D413/14; C07D417/14; C07D471/04; C07D473/08; C07D495/04; (IPC1-7): C07D413/14; C07D401/14; C07D417/14; C07D471/04; A61K31/4184; A61P7/02; C07D413/14; C07D401/12; C07D451/06; C07D413/12; C07D409/14; C07D473/08; C07D495/04

View/Download PDF      PDF Help

Previous Patent: OXAZOLIDINONE DERIVATIVES AS ANTIBACTERIAL AGENTS

Next Patent: HETEROCYCLIC COMPOUNDS