Title:
BACTERIA-TARGETING CAPSID PARTICLE, TREATMENT COMPOSITION, DISINFECTANT, FOOD, METHOD FOR ELIMINATING BACTERIA, STERILIZATION METHOD, METHOD FOR PREVENTING DECAY, METHOD FOR TREATING ANIMAL, METHOD FOR INTRODUCING GENE, METHOD FOR ADDING BACTERIA FUNCTION, METHOD FOR PRODUCING BACTERIA-TARGETING CAPSID PARTICLE, AND METHOD FOR PRODUCING NUCLEIC ACID FOR BACTERIA-TARGETING CAPSID PARTICLE
Document Type and Number:
WIPO Patent Application WO/2024/004923
Kind Code:
A1
Abstract:
The present invention provides a bacteria-targeting capsid particle that is non-proliferating and that has a high bactericidal effect. A capsid protein of a phage is prepared with a capsid nucleic acid element that is separated from a phage genome, that does not include a packaging region, that mainly includes a virion region, and that synthesizes a capsid. An element for a bacteria-targeting capsid particle (B-CAP) includes a nucleic acid injection region, a replication region necessary for nucleic acid replication, and a packaging region which are separated from a portion of a phage genome other than a capsid nucleic acid element. A bacteria-targeting capsid particle (B-CAP) in which these are assembled is non-proliferating and enables inclusion of long-chain DNA which gives a new biological function including a bactericidal effect.
Inventors:
CUI LONGZHU (JP)
KIGA KOTARO (JP)
KIGA KOTARO (JP)
Application Number:
PCT/JP2023/023521
Publication Date:
January 04, 2024
Filing Date:
June 26, 2023
Export Citation:
Assignee:
UNIV JICHI MEDICAL (JP)
International Classes:
A61K35/76; C12N7/01; A61K48/00; A61P31/04; C12N15/31; C12N15/70; C12N15/74
Domestic Patent References:
| WO2019225246A1 | 2019-11-28 |
Other References:
KIGA KOTARO, TAN XIN-EE, IBARRA-CHÁVEZ RODRIGO, WATANABE SHINYA, AIBA YOSHIFUMI, SATO’O YUSUKE, LI FENG-YU, SASAHARA TEPPEI, CUI B: "Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria", NATURE COMMUNICATIONS, vol. 11, no. 1, 1 December 2020 (2020-12-01), XP055888259, DOI: 10.1038/s41467-020-16731-6
AZAM AA HAERUMAN, TAN XIN-EE, VEERANARAYANAN SRIVANI, KIGA KOTARO, CUI LONGZHU: "Bacteriophage Technology and Modern Medicine", ANTIBIOTICS (BASEL, SWITZERLAND) 2015, vol. 10, no. 8, pages 999, XP093124981, ISSN: 2079-6382, DOI: 10.3390/antibiotics10080999
KIGA, KOTARO; CUI, LONGZHU: "New strategies for cell therapy III. Utilization of microorganisms and nanostructures 15. Phage technology and modern medicine", EXPERIMENTAL MEDICINE, YODOSHA CO., LTD., JP, vol. 38, no. 17, 1 January 2020 (2020-01-01), JP , pages 2999 - 3005, XP009552230, ISSN: 0288-5514
AZAM AA HAERUMAN, TAN XIN-EE, VEERANARAYANAN SRIVANI, KIGA KOTARO, CUI LONGZHU: "Bacteriophage Technology and Modern Medicine", ANTIBIOTICS (BASEL, SWITZERLAND) 2015, vol. 10, no. 8, pages 999, XP093124981, ISSN: 2079-6382, DOI: 10.3390/antibiotics10080999
KIGA, KOTARO; CUI, LONGZHU: "New strategies for cell therapy III. Utilization of microorganisms and nanostructures 15. Phage technology and modern medicine", EXPERIMENTAL MEDICINE, YODOSHA CO., LTD., JP, vol. 38, no. 17, 1 January 2020 (2020-01-01), JP , pages 2999 - 3005, XP009552230, ISSN: 0288-5514
Attorney, Agent or Firm:
HORI, Shiroyuki et al. (JP)
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