Title:
BACTERIAL CELL DIGESTION BY MEANS OF DOMAIN 3 OF EF-TU
Document Type and Number:
WIPO Patent Application WO2004005506
Kind Code:
A3
Abstract:
The invention relates to the use of substances which bind to the bacterial elongation factor EF-Tu for cell digestion or for the lysis of cells. The invention further relates to a cell digestion system and a cell digestion method.
Inventors:
MAYER FRANK (DE)
SCHWIENHORST ANDREAS (DE)
SCHWIENHORST ANDREAS (DE)
Application Number:
PCT/EP2003/007068
Publication Date:
May 06, 2004
Filing Date:
July 02, 2003
Export Citation:
Assignee:
NOVOLOGIX GMBH (DE)
MAYER FRANK (DE)
SCHWIENHORST ANDREAS (DE)
MAYER FRANK (DE)
SCHWIENHORST ANDREAS (DE)
International Classes:
C12N1/06; C12N15/12; (IPC1-7): C12N1/06; C07K14/47; C12N15/12; C12P21/00
Foreign References:
| DE19929485A1 | 2001-01-11 |
Other References:
SONG H ET AL: "Crystal structure of intact elongation factor EF-Tu from Escherichia coli in GDP conformation at 2.05 A resolution", JOURNAL OF MOLECULAR BIOLOGY 22 JAN 1999 UNITED KINGDOM, vol. 285, no. 3, 22 January 1999 (1999-01-22), pages 1245 - 1256, XP002270308, ISSN: 0022-2836
HEFFRON S E ET AL: "Structure of an EF-Tu complex with a thiazolyl peptide antibiotic determined at 2.35 A resolution: atomic basis for GE2270A inhibition of EF-Tu.", BIOCHEMISTRY. UNITED STATES 11 JAN 2000, vol. 39, no. 1, 11 January 2000 (2000-01-11), pages 37 - 45, XP001172470, ISSN: 0006-2960
HOGG T ET AL: "Inhibitory mechanisms of antibiotics targeting elongation factor Tu.", CURRENT PROTEIN & PEPTIDE SCIENCE. NETHERLANDS FEB 2002, vol. 3, no. 1, February 2002 (2002-02-01), pages 121 - 131, XP002270310, ISSN: 1389-2037
See also references of EP 1517986A2
HEFFRON S E ET AL: "Structure of an EF-Tu complex with a thiazolyl peptide antibiotic determined at 2.35 A resolution: atomic basis for GE2270A inhibition of EF-Tu.", BIOCHEMISTRY. UNITED STATES 11 JAN 2000, vol. 39, no. 1, 11 January 2000 (2000-01-11), pages 37 - 45, XP001172470, ISSN: 0006-2960
HOGG T ET AL: "Inhibitory mechanisms of antibiotics targeting elongation factor Tu.", CURRENT PROTEIN & PEPTIDE SCIENCE. NETHERLANDS FEB 2002, vol. 3, no. 1, February 2002 (2002-02-01), pages 121 - 131, XP002270310, ISSN: 1389-2037
See also references of EP 1517986A2
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