BACTERIAL ENZYME INHIBITORS - NOVO PHARMACEUTICALS LTD DE

Title:

BACTERIAL ENZYME INHIBITORS

Document Type and Number:

WIPO Patent Application WO2003048114

Kind Code:

A3

Abstract:

Compounds of formula (I), are antibacterial agents, wherein: Z represents a radical of formula -N(OH)CH(=O) or of formula -C(=O)NH(OH); X represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical; n is O or 1; and R represents an optionally substituted carbocyclic or heterocyclic group.

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Inventors:

GANE PAUL (GB)
PORTER BARRY (GB)
SAROGLOU LYDIA (GB)
WILLEMS HENRIETTE (GB)
WIJKMANS JAC (NL)

Application Number:

PCT/GB2002/005347

Publication Date:

July 17, 2003

Filing Date:

November 27, 2002

Export Citation:

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Assignee:

NOVO PHARMACEUTICALS LTD DE (GB)
GANE PAUL (GB)
PORTER BARRY (GB)
SAROGLOU LYDIA (GB)
WILLEMS HENRIETTE (GB)
WIJKMANS JAC (NL)

International Classes:

A61P31/04; C07C259/06; (IPC1-7): C07C259/06; A61K31/16; A61P31/04; C12Q1/00

Domestic Patent References:

WO2000061134A1	2000-10-19
WO2001038561A1	2001-05-31
WO2002026696A1	2002-04-04

Foreign References:

US4122186A

1978-10-24

Other References:

ZIEGLER, ERICH ET AL: "Synthesis of functionally mixed malonic acid derivatives", MONATSHEFTE FUER CHEMIE (1967), 98(3), 1100-3, XP002241662

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