Title:
BCMA-TARGETED CAR-T CELL THERAPY FOR MULTIPLE MYELOMA
Document Type and Number:
WIPO Patent Application WO/2022/117068
Kind Code:
A1
Abstract:
Provided herein is a method of treating a subject who has multiple myeloma. A single infusion of chimeric antigen receptor (CAR) -T cells comprising an anti-BCMA CAR comprising a polypeptide is administered to the subject. In certain embodiments, the dose of CAR-T cells administered to the subject is from 1.0 x 10 5 to 5.0 x 10 6 of CAR-T cells per kilogram of the subject's mass. The method of treatment is effective in obtaining and maintaining minimal residual disease negativity status, as well as other beneficial clinical outcomes related to efficacy and safety.
Inventors:
SCHECTER JORDAN MARK (US)
FAN XIAOHU (CA)
FAN XIAOHU (CA)
Application Number:
PCT/CN2021/135295
Publication Date:
June 09, 2022
Filing Date:
December 03, 2021
Export Citation:
Assignee:
JANSSEN BIOTECH INC (US)
NANJING LEGEND BIOTECH CO LTD (CN)
NANJING LEGEND BIOTECH CO LTD (CN)
International Classes:
A61K35/17; A61P35/00; C07K14/705
Domestic Patent References:
| WO2020020359A1 | 2020-01-30 | |||
| WO2017025038A1 | 2017-02-16 | |||
| WO1992008796A1 | 1992-05-29 | |||
| WO1994028143A1 | 1994-12-08 | |||
| WO2018028647A1 | 2018-02-15 |
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| EP3475307A1 | 2019-05-01 | |||
| US20090093024A1 | 2009-04-09 | |||
| US5464758A | 1995-11-07 | |||
| US5814618A | 1998-09-29 | |||
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| US5122464A | 1992-06-16 | |||
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HOLLIGER ET AL., NAT. BIOTECH., vol. 23, no. 9, 2005, pages 1126 - 1129
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 5879 - 5883
OSBOURN ET AL., NAT. BIOTECHNOL, vol. 16, 1998, pages 778
JOHNSTON, NATURE, vol. 346, 1990, pages 776 - 777
NO ET AL., PROC. NATL. ACAD. SCI., vol. 93, 1996, pages 3346 - 3351
INDRA ET AL., NUC. ACID. RES., vol. 27, 1999, pages 4324 - 4327
NUC. ACID. RES., vol. 28, 2000, pages e99
KRAMERFUSSENEGGER, METHODS MOL. BIOL, vol. 308, 2005, pages 123 - 144
"Fundamental Immunology", 1993, RAVEN PRESS, pages: 353 - 363
WIGLER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 3567
O'HARE ET AL., PROC. NATL. ACAD. SCI. USA, vol. 78, 1981, pages 2072
COLBERRE-GARAPIN ET AL., J. MOL. BIOL., vol. 150, 1981, pages 1
SANTERRE ET AL., GENE, vol. 30, 1984, pages 147
KENT ET AL., SCIENCE, vol. 237, 1987, pages 901 - 903
WIGLER ET AL., CELL, 1977, pages 223
SZYBALSKASZYBALSKI, PROC. NATL. ACAD. SCI. USA, vol. 48, 1962, pages 2026
LOWY ET AL., CELL, vol. 22, 1980, pages 817
CONESE ET AL., GENE THERAPY, vol. 11, 2004, pages 1735 - 1742
"Immunobiology", 2001, GARLAND PUBLISHING
BRASH ET AL., MOL. CELL BIOL., vol. 7, 1987, pages 2031 - 2034
RESTIFO, BLOOD, vol. 4, 2014, pages 476 - 77
JOSHI ET AL., J. IMMUNOL., vol. 3, 2008, pages 1309 - 15
GATTINONI ET AL., NAT. MED., vol. 17, 2011, pages 1290 - 7
FLYNN ET AL., CLIN. TRANSLAT. IMMUNOL., vol. 3, 2014, pages e20
SZOKA ET AL., ANN. REV. BIOPHYS. BIOENG., vol. 9, 1980, pages 467
KOCHENDERFER ET AL., J. IMMUNOTHERAPY, vol. 32, no. 7, 2009, pages 689 - 702
HERMAN ET AL., J. IMMUNOLOGICAL METHODS, vol. 285, no. 1, 2004, pages 25 - 40
Attorney, Agent or Firm:
CHINA PATENT AGENT (H.K.) LTD. (CN)
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