Title:
BENZAZEPINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2019/003433
Kind Code:
A1
Abstract:
The present invention provides: a novel benzazepine compound which is represented by formula (1) and has vasopressin V1a and V2 antagonism, or a salt thereof; and a pharmaceutical use thereof. [In formula, R1 represents optionally substituted C1-6 alkyl and the like; L represents -C(═O)-NH- and the like; ring A1 represents a hydrocarbon ring and the like; ring A2
, represents a hydrocarbon ring and the like; the rings A1 and A2 each may have at least one substituent.]
Inventors:
KAN KEIZO (JP)
TAKUWA MASATOSHI (JP)
TANAKA HIROTAKA (JP)
FUJIWARA HIDETO (JP)
YAMABE HOKUTO (JP)
MATSUDA SATOSHI (JP)
OHDACHI KAZUHIRO (JP)
HANARI TAIKI (JP)
MENJO YASUHIRO (JP)
URUSHIMA TATSUYA (JP)
FUJITA SHIGEKAZU (JP)
TAKUWA MASATOSHI (JP)
TANAKA HIROTAKA (JP)
FUJIWARA HIDETO (JP)
YAMABE HOKUTO (JP)
MATSUDA SATOSHI (JP)
OHDACHI KAZUHIRO (JP)
HANARI TAIKI (JP)
MENJO YASUHIRO (JP)
URUSHIMA TATSUYA (JP)
FUJITA SHIGEKAZU (JP)
Application Number:
PCT/JP2017/024211
Publication Date:
January 03, 2019
Filing Date:
June 30, 2017
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
International Classes:
C07D401/06; A61K31/55; A61P1/16; A61P3/10; A61P7/00; A61P7/10; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P27/16; C07D223/16; C07D401/14
Domestic Patent References:
| WO2011052519A1 | 2011-05-05 | |||
| WO1995006035A1 | 1995-03-02 |
Foreign References:
| JP2000212165A | 2000-08-02 | |||
| JP2008509972A | 2008-04-03 | |||
| JP2016513112A | 2016-05-12 | |||
| JP2000351768A | 2000-12-19 |
Other References:
YEA, CHRISTOPHER M. ET AL.: "New Benzylureas as a Novel Series of Potent, Nonpeptidic Vasopressin V2 Receptor Agonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 24, 24 November 2008 (2008-11-24), pages 8124 - 8134, XP002638571
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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