Title:
BENZAZEPINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2019/004421
Kind Code:
A1
Abstract:
The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin V1a and V2 antagonisms, and medical uses thereof. In the formula, R1 is optionally substituted C1-6 alkyl, etc.; L is -C(=O)-NH-, etc.; Ring A1 is a hydrocarbon ring, etc.; Ring A2 is a hydrocarbon ring, etc.; and each of Rings A1 and A2 may have at least one substituent.
Inventors:
KAN KEIZO (JP)
TAKUWA MASATOSHI (JP)
TANAKA HIROTAKA (JP)
FUJIWARA HIDETO (JP)
YAMABE HOKUTO (JP)
MATSUDA SATOSHI (JP)
OHDACHI KAZUHIRO (JP)
HANARI TAIKI (JP)
MENJO YASUHIRO (JP)
URUSHIMA TATSUYA (JP)
FUJITA SHIGEKAZU (JP)
TAKUWA MASATOSHI (JP)
TANAKA HIROTAKA (JP)
FUJIWARA HIDETO (JP)
YAMABE HOKUTO (JP)
MATSUDA SATOSHI (JP)
OHDACHI KAZUHIRO (JP)
HANARI TAIKI (JP)
MENJO YASUHIRO (JP)
URUSHIMA TATSUYA (JP)
FUJITA SHIGEKAZU (JP)
Application Number:
PCT/JP2018/024786
Publication Date:
January 03, 2019
Filing Date:
June 29, 2018
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
International Classes:
C07D223/16; A61K31/55; A61P13/12; C07D401/06; C07D401/10; C07D401/14; C07D403/06; C07D405/12; C07D409/12
Domestic Patent References:
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| WO1994004525A1 | 1994-03-03 | |||
| WO1994001113A1 | 1994-01-20 | |||
| WO1991005549A1 | 1991-05-02 | |||
| WO1995034540A1 | 1995-12-21 | |||
| WO1994008582A1 | 1994-04-28 | |||
| WO2015056805A1 | 2015-04-23 |
Foreign References:
| EP2495236A1 | 2012-09-05 | |||
| EP0716083A1 | 1996-06-12 | |||
| US5258510A | 1993-11-02 | |||
| JPH10120592A | 1998-05-12 | |||
| JPH09221476A | 1997-08-26 | |||
| JPH04321669A | 1992-11-11 |
Other References:
KAZUMI KONDO ET AL: "7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl- amino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine (OPC-41061): A Potent, Orally Active Nonpeptide Arginine Vasopressin V 2 Receptor Antagonist", BIOORG. MED. CHEM., vol. 7, 1 August 1999 (1999-08-01), pages 1743 - 1754, XP055503210
SHOAF S.E. ET AL., BR J CLIN PHARMACOL., vol. 73, 2011, pages 579 - 87
SORBERA L.A. ET AL., DRUGS OF THE FUTURE, vol. 27, no. 4, 2002, pages 350 - 357
FURUKAWA M. ET AL., ARCH. PHARM. RES. ARCH. PHARM. RES., vol. 37, 2014, pages 1578 - 87
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS, INC.
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS, pages: 309
SHIGERU OOBA; SHIGENOBU YANO: "Kagakusha no tame no Kisokoza 12 X-ray crystallography", 1999
WALDEMAR ADAM; RAINER T. FELL; CHANTU R. SAHA-MOLLER; CONG-GUI ZHAO, TETRAHEDRON: ASYMMETRY, vol. 9, 1998, pages 397 - 401
YUANMING ZHU; YONG TU; HONGWU YU; YIAN SHI, TETRAHEDRON LETT., vol. 29, 1988, pages 2437 - 2440
R. S. OBACH, DRUG METAB. DISPOS., vol. 27, 1999, pages 1350 - 1359
H. JONES; J. B. HOUSTON, DRUG METAB. DISPOS., vol. 32, 2004, pages 973 - 982
SHOAF S.E. ET AL., BR J CLIN PHARMACOL., vol. 73, 2011, pages 579 - 87
SORBERA L.A. ET AL., DRUGS OF THE FUTURE, vol. 27, no. 4, 2002, pages 350 - 357
FURUKAWA M. ET AL., ARCH. PHARM. RES. ARCH. PHARM. RES., vol. 37, 2014, pages 1578 - 87
"ORGANIC FUNCTIONAL GROUP PREPARATIONS", 1989, ACADEMIC PRESS, INC.
"Comprehensive Organic Transformations", 1989, VCH PUBLISHERS INC.
P. G. M. WUTS; T. W. GREENE: "Greene's Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS, pages: 309
SHIGERU OOBA; SHIGENOBU YANO: "Kagakusha no tame no Kisokoza 12 X-ray crystallography", 1999
WALDEMAR ADAM; RAINER T. FELL; CHANTU R. SAHA-MOLLER; CONG-GUI ZHAO, TETRAHEDRON: ASYMMETRY, vol. 9, 1998, pages 397 - 401
YUANMING ZHU; YONG TU; HONGWU YU; YIAN SHI, TETRAHEDRON LETT., vol. 29, 1988, pages 2437 - 2440
R. S. OBACH, DRUG METAB. DISPOS., vol. 27, 1999, pages 1350 - 1359
H. JONES; J. B. HOUSTON, DRUG METAB. DISPOS., vol. 32, 2004, pages 973 - 982
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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