Title:
HETERO DOUBLE-STRANDED antimiR
Document Type and Number:
WIPO Patent Application WO/2019/004420
Kind Code:
A1
Abstract:
Provided is a nucleic acid that inhibits the function of a target miRNA. A double-stranded nucleic acid complex containing a first nucleic acid strand, which has a base length of 6-30 and hybridizes with the target miRNA to thereby inhibit the function of the target miRNA, and a second nucleic acid strand which is complementary to the fist nucleic acid strand, wherein: the first nucleic acid strand is a mixmer comprising a natural nucleoside and a non-natural nucleoside; and the second nucleic acid strand contains one or more inter-modified nucleoside bonds and/or one or more sugar-modified nucleosides.
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Inventors:
YOKOTA TAKANORI (JP)
YOSHIOKA KOTARO (JP)
YOSHIOKA KOTARO (JP)
Application Number:
PCT/JP2018/024785
Publication Date:
January 03, 2019
Filing Date:
June 29, 2018
Export Citation:
Assignee:
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
International Classes:
C12N15/113; A61K31/7088; A61K48/00; A61P43/00
Domestic Patent References:
| WO2018062510A1 | 2018-04-05 | |||
| WO2010047216A1 | 2010-04-29 | |||
| WO2011130371A1 | 2011-10-20 | |||
| WO2013089283A1 | 2013-06-20 | |||
| WO2014203518A1 | 2014-12-24 | |||
| WO2014132671A1 | 2014-09-04 | |||
| WO2014192310A1 | 2014-12-04 | |||
| WO2007143315A2 | 2007-12-13 | |||
| WO2008043753A2 | 2008-04-17 | |||
| WO2008049085A1 | 2008-04-24 |
Foreign References:
| JP2015502134A | 2015-01-22 | |||
| JP2016524588A | 2016-08-18 | |||
| JP2016509837A | 2016-04-04 | |||
| US20100286378A1 | 2010-11-11 | |||
| JP2017129594A | 2017-07-27 |
Other References:
JANSSEN HL ET AL.: "Treatment of HCV Infection by Targeting MicroRNA", N. ENGL. J. MED., vol. 368, no. 18, 2013, pages 1685 - 1694, XP055227943, DOI: 10.1056/NEJMoa1209026
ELMEN J ET AL.: "LNA-mediated microRNA silencing in non-human primates", NATURE, vol. 452, no. 7189, 2008, pages 896 - 899
WAGENAAR TR ET AL.: "Anti-miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation", MOL. CANCER RES., vol. 13, no. 6, 2015, pages 1009 - 1021
LI ZRANA TM, NATURE REVIEWS DRUG DISCOVERY, vol. 13, 2014, pages 622 - 638
KOZOMARA AGRIFFITHS-JONES S, NAR, vol. 42, 2014, pages D68 - D73
KOZOMARA AGRIFFITHS-JONES S, NAR, vol. 39, 2011, pages D152 - D157
GRIFFITHS-JONES SSAINI HKVAN DONGEN SENRIGHT AJ, NAR, vol. 36, 2008, pages D154 - D158
GRIFFITHS-JONES SGROCOCK RJVAN DONGEN SBATEMAN AENRIGHT AJ, NAR, vol. 34, 2006, pages D140 - D144
GRIFFITHS-JONES S, NAR, vol. 32, 2004, pages D109 - D111
HAIFANG YIN ET AL., HUMAN MOLECULAR GENETICS, vol. 17, no. 24, 2008, pages 3909 - 3918
See also references of EP 3647423A4
ELMEN J ET AL.: "LNA-mediated microRNA silencing in non-human primates", NATURE, vol. 452, no. 7189, 2008, pages 896 - 899
WAGENAAR TR ET AL.: "Anti-miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation", MOL. CANCER RES., vol. 13, no. 6, 2015, pages 1009 - 1021
LI ZRANA TM, NATURE REVIEWS DRUG DISCOVERY, vol. 13, 2014, pages 622 - 638
KOZOMARA AGRIFFITHS-JONES S, NAR, vol. 42, 2014, pages D68 - D73
KOZOMARA AGRIFFITHS-JONES S, NAR, vol. 39, 2011, pages D152 - D157
GRIFFITHS-JONES SSAINI HKVAN DONGEN SENRIGHT AJ, NAR, vol. 36, 2008, pages D154 - D158
GRIFFITHS-JONES SGROCOCK RJVAN DONGEN SBATEMAN AENRIGHT AJ, NAR, vol. 34, 2006, pages D140 - D144
GRIFFITHS-JONES S, NAR, vol. 32, 2004, pages D109 - D111
HAIFANG YIN ET AL., HUMAN MOLECULAR GENETICS, vol. 17, no. 24, 2008, pages 3909 - 3918
See also references of EP 3647423A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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