Title:
BENZO[D]ISOXAZOLE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/217063
Kind Code:
A1
Abstract:
The present application provides a benzo[d]isoxazole compound and use thereof. The compound has a structure represented by the following formula I. The benzo[d]isoxazole compound of the present application can induce the degradation of BET protein and/or GSPT1 protein, and has an anti-proliferation effect on cancer cells. Therefore, the compound provided by the present application and a composition comprising same can be used for preparing a drug for treating or preventing a disease such as oncogenesis, an inflammation, a virus infection, a cell proliferative disorder, an autoimmune disease, and septicemia.
Inventors:
XU YONG (CN)
SHEN HUI (CN)
XU HONGRUI (CN)
WU TIANBANG (CN)
ZHANG CHENG (CN)
YU HAONAN (CN)
HU JIANKANG (CN)
LUO GUOLONG (CN)
LI JUNHUA (CN)
LU JIBU (CN)
WU XISHAN (CN)
ZHANG YAN (CN)
SHEN HUI (CN)
XU HONGRUI (CN)
WU TIANBANG (CN)
ZHANG CHENG (CN)
YU HAONAN (CN)
HU JIANKANG (CN)
LUO GUOLONG (CN)
LI JUNHUA (CN)
LU JIBU (CN)
WU XISHAN (CN)
ZHANG YAN (CN)
Application Number:
PCT/CN2023/092667
Publication Date:
November 16, 2023
Filing Date:
May 08, 2023
Export Citation:
Assignee:
GUANGZHOU IMD THERAPEUTICS CO LTD (CN)
International Classes:
C07D413/14; A61K31/5377; A61P31/12; A61P37/00; C07D401/14; C07D409/14; C07D417/14
Domestic Patent References:
| WO2020264490A1 | 2020-12-30 |
Foreign References:
| CN111989322A | 2020-11-24 | |||
| CN105085427A | 2015-11-25 | |||
| CN109111437A | 2019-01-01 | |||
| CN110963994A | 2020-04-07 | |||
| CN111902141A | 2020-11-06 | |||
| CN112745298A | 2021-05-04 | |||
| CN113527260A | 2021-10-22 | |||
| CN113651766A | 2021-11-16 |
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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