Title:
CAMPTOTHECIN DERIVATIVE, ANTIBODY-DRUG CONJUGATE AND PHARMACEUTICAL COMPOSITION BASED ON SAME, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/217064
Kind Code:
A1
Abstract:
The present invention belongs to the field of pharmaceutical chemistry, and relates to a camptothecin derivative, an antibody-drug conjugate and pharmaceutical composition based on same, and the use thereof. The derivative has a structure as represented by formula (I), has a good inhibitory activity on DNA topoisomerase (I) and a tumor cell killing effect, so that the derivative can be used for preventing and/or treating diseases (such as cancer) that are at least partially related to TOP1, and has great development prospects.
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Inventors:
JIANG SHANJUN (CN)
QIAN GANG (CN)
CHEN FENG (CN)
WANG GUITAO (CN)
ZHANG NAN (CN)
HUANG BAOHUA (CN)
QIAN GANG (CN)
CHEN FENG (CN)
WANG GUITAO (CN)
ZHANG NAN (CN)
HUANG BAOHUA (CN)
Application Number:
PCT/CN2023/092670
Publication Date:
November 16, 2023
Filing Date:
May 08, 2023
Export Citation:
Assignee:
COHERENT BIOPHARMA SUZHOU LTD (CN)
International Classes:
C07D491/22; A61K31/4745; A61P35/00; A61P35/02
Domestic Patent References:
| WO2023004266A1 | 2023-01-26 | |||
| WO2022236136A1 | 2022-11-10 | |||
| WO2022166762A1 | 2022-08-11 | |||
| WO2022068878A1 | 2022-04-07 | |||
| WO2022015656A1 | 2022-01-20 | |||
| WO2022056696A1 | 2022-03-24 | |||
| WO2022078260A1 | 2022-04-21 |
Foreign References:
| CN115850291A | 2023-03-28 | |||
| CN111689980A | 2020-09-22 | |||
| CN112125915A | 2020-12-25 | |||
| CN113827736A | 2021-12-24 |
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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