Title:
BENZOTHIOPHENE ALKANOL PIPERAZINE DERIVATIVES AND THEIR USE AS ANTIDEPRESSANT
Document Type and Number:
WIPO Patent Application WO/2010/000198
Kind Code:
A1
Abstract:
The invention discloses benzothiophene alkanol piperazine derivatives and their use as antidepressants. The invention discloses the said benzothiophene alkanol piperazine derivatives having triple inhibition effect on the reuptake of 5-HT, NA and DA. Compared with clinical used antidepressants so far having single effect, e.g. desipramine and fluoxetine, and clinical used antidepressants so far having double effect, e.g venlafaxine and duloxetine, the said benzothiophene alkanol piperazine derivatives of the present invention maybe have a broader indication range and less toxic and side effects to nervous system. The said benzothiophene alkanol piperazine derivatives are the compounds with the following formula or their pharmaceutical salts, wherein Ar1, R1-R4, X, Y, m and n have the same definition as defined in claim 1.
Inventors:
LI JIANQI (CN)
GAO KAI (CN)
LV NA (CN)
GAO KAI (CN)
LV NA (CN)
Application Number:
PCT/CN2009/072534
Publication Date:
January 07, 2010
Filing Date:
June 30, 2009
Export Citation:
Assignee:
CSPC ZHONGQI PHARMACEUTICAL TE (CN)
SHANGHAI INST PHARM INDUSTRY (CN)
LI JIANQI (CN)
GAO KAI (CN)
LV NA (CN)
SHANGHAI INST PHARM INDUSTRY (CN)
LI JIANQI (CN)
GAO KAI (CN)
LV NA (CN)
International Classes:
C07D409/06; A61K31/496; A61P25/24; C07D409/14
Foreign References:
| CN1935807A | 2007-03-28 | |||
| CN1812984A | 2006-08-02 | |||
| CN1384102A | 2002-12-11 | |||
| CN1948297A | 2007-04-18 |
Other References:
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 68: 12797, XP008142514
MARON DM ET AL., MUTAYRES., vol. 113, 61119, pages 173 - 216
See also references of EP 2311828A4
MARON DM ET AL., MUTAYRES., vol. 113, 61119, pages 173 - 216
See also references of EP 2311828A4
Attorney, Agent or Firm:
CHINA SCIENCE PATENT AND TRADEMARK AGENT LTD. (Bldg. B Tsinghua Tongfang Hi-Tech Plaza,,No.1, Wangzhuang Rd.,Haidian District, Beijing 3, CN)
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