BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS

Title:

BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS

Document Type and Number:

WIPO Patent Application WO2004092124

Kind Code:

A3

Abstract:

Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula (I): which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.

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Inventors:

GOBLE STEPHEN D (US)
MILLS SANDER G (US)
YANG LIHU (US)
PASTERNAK ALEXANDER (US)

Application Number:

PCT/US2004/011281

Publication Date:

April 14, 2005

Filing Date:

April 09, 2004

Export Citation:

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Assignee:

MERCK & CO INC (US)
GOBLE STEPHEN D (US)
MILLS SANDER G (US)
YANG LIHU (US)
PASTERNAK ALEXANDER (US)

International Classes:

A61K31/535; A61K31/55; A61P29/00; C07D243/00; C07D265/12; C07D401/00; C07D413/00; C07D413/08; C07D413/14; C07D417/00; C07D417/14; C07D498/04; C07D519/00; A61K; C07D; (IPC1-7): A61P29/00; A61K31/55; A61K31/535; C07D243/00; C07D265/12; C07D401/00; C07D413/00; C07D417/00

Foreign References:

US6812234B2

2004-11-02

Other References: