BENZYL PIPERAZINE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF IN ANTIVIRUS

WIPO Patent Application WO/2021/102600

A1

Disclosed are a benzyl piperazine compound, a preparation method therefor and an application thereof in an antivirus. The benzyl piperazine compound has a structure represented by the following general formula (I). It is proven by experiments that the benzyl piperazine compound not only has significant antiviral activity, but also has the advantages of low cytotoxicity, a high selectivity index and so on.

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WO/2017/038627	NOVEL DIAMINE COMPOUND HAVING RADICAL GENERATION ABILITY AND BASE GENERATION ABILITY, AND NOVEL IMIDE POLYMER USING SAID NOVEL DIAMINE COMPOUND AS STARTING MATERIAL
JP2005002118	COMPOUND FOR TREATING ASTHMA, ALLERGY, AND INFLAMMATORY DISEASE AND METHOD FOR THE SAME

LI YANPING (CN)
LI ZHUORONG (CN)
PENG ZONGGEN (CN)
JIANG XINBEI (CN)
WANG YIXUAN (CN)
LI JIANRUI (CN)
TAN JIALI (CN)

PCT/CN2019/000232

June 03, 2021

November 29, 2019

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INST MED BIOTECHNOLOGY CAMS (CN)

C07D295/135; A61K31/445; A61K31/495; A61P31/14; A61P31/16; A61P31/20; C07D207/09; C07D207/325; C07D211/26; C07D211/56; C07D295/155

CN106467501A	2017-03-01
CN110698432A	2020-01-17

ROMERO, D.L. ET AL.: "Discovery, Synthesis, and Bioactivity of Bis(heteroaryl)piperazines. 1. A Novel Class of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, no. 7, 1 April 1994 (1994-04-01), XP002345620, ISSN: 0022-2623, DOI: 10.1021/jm00033a018

KELONG INTERNATIONAL INTELLECTUAL PROPERTY AGENT LTD. (CN)

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