Title:
BICYCLIC SUBSTITUTED AROMATIC CARBOXYLIC ACID COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2022/218429
Kind Code:
A1
Abstract:
The present application relates to a bicyclic substituted aromatic carboxylic acid compound, and in particular to a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof. In formula (I), R2 and R3 and atoms connected thereto together form a 3-6 membered heterocyclic group, or R2 and R4 and atoms connected thereto together form a 3-6 membered heterocyclic group. The compound has obvious inhibitory activity on activation of a human serum alternative pathway and significant binding activity to human complement Factor B protein, and also has relatively good in-vivo pharmacodynamic and pharmacokinetic properties.
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Inventors:
DING CHARLES Z (CN)
YAN XIAOBING (CN)
SUN FEI (CN)
JIANG WEN (CN)
LI JIAN (CN)
CHEN SHUHUI (CN)
YAN XIAOBING (CN)
SUN FEI (CN)
JIANG WEN (CN)
LI JIAN (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2022/087226
Publication Date:
October 20, 2022
Filing Date:
April 15, 2022
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
MEDSHINE DISCOVERY INC (CN)
MEDSHINE DISCOVERY INC (CN)
International Classes:
A61K31/454; C07D401/14; A61P27/00; C07D209/02; C07D401/06; C07D413/14
Domestic Patent References:
| WO2022028527A1 | 2022-02-10 |
Foreign References:
| CN114057758A | 2022-02-18 | |||
| CN109414441A | 2019-03-01 | |||
| CN112513025A | 2021-03-16 | |||
| CN105579444A | 2016-05-11 |
Other References:
MAINOLFI NELLO, EHARA TAKERU, KARKI RAJESHRI G., ANDERSON KAREN, MAC SWEENEY AENGUS, LIAO SHA-MEI, ARGIKAR UPENDRA A., JENDZA KEIT: "Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 11, 11 June 2020 (2020-06-11), US , pages 5697 - 5722, XP055791648, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01870
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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