Title:
BIFIDOBACTERIUM SPP. EXPRESSING AND SECRETING DIABODY-TYPE BSAB
Document Type and Number:
WIPO Patent Application WO/2021/038975
Kind Code:
A1
Abstract:
A problem addressed by the present invention is to provide Bifidobacterium spp. that exert a persistent, specific antitumor effect on solid cancers.　Bifidobacterium spp. that express a first polypeptide including a light chain variable region (VL) that binds to human CD3 and a heavy chain variable region (VH) that binds to a human tumor cell surface antigen and a second polypeptide including a VL that binds to a human tumor cell surface antigen and a VH that binds to human CD3, and secrete a diabody-type bispecific antibody constructed from the first polypeptide and the second polypeptide are produced.
Inventors:
SHIMATANI YUKO (JP)
KOBAYASHI SATOSHI (JP)
SHIOYA KOICHIRO (JP)
KATAOKA SHIRO (JP)
SEKI YUJI (JP)
MATSUMURA TOMIO (JP)
KANARI YASUYOSHI (JP)
UMETSU MITSUO (JP)
NAKAZAWA HIKARU (JP)
KOBAYASHI SATOSHI (JP)
SHIOYA KOICHIRO (JP)
KATAOKA SHIRO (JP)
SEKI YUJI (JP)
MATSUMURA TOMIO (JP)
KANARI YASUYOSHI (JP)
UMETSU MITSUO (JP)
NAKAZAWA HIKARU (JP)
Application Number:
PCT/JP2020/019075
Publication Date:
March 04, 2021
Filing Date:
May 13, 2020
Export Citation:
Assignee:
ANAEROPHARMA SCIENCE INC (JP)
UNIV TOHOKU (JP)
UNIV TOHOKU (JP)
International Classes:
A61K39/395; A61K31/7016; A61K35/745; A61K47/26; A61P35/00; A61P43/00; C07K16/46; C12N1/21; C12N15/13
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Other References:
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SCI REP, vol. 7, no. 1, 6 June 2017 (2017-06-06), pages 2862
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J MICROBIOL, vol. 50, no. 4, August 2012 (2012-08-01), pages 638 - 43
JMICROBIOL, vol. 50, no. 4, August 2012 (2012-08-01), pages 638 - 43
BIOSCI BIOTECHNOL BIOCHEM., vol. 69, no. 2, February 2005 (2005-02-01), pages 422 - 5
LETT APPL MICROBIOL, vol. ll, no. 4, October 1990 (1990-10-01), pages 220 - 3
J MICROBIOL BIOTECHNOL, vol. 19, no. 4, April 2009 (2009-04-01), pages 403 - 8
APPL ENVIRON MICROBIOL, vol. 73, no. 24, December 2007 (2007-12-01), pages 7858 - 66
PLASMID, vol. 57, no. 2, March 2007 (2007-03-01), pages 165 - 74
APPL ENVIRON MICROBIOL, vol. 72, no. 1, January 2006 (2006-01-01), pages 527 - 35
MICROBIOLOGY, vol. 145, March 1999 (1999-03-01), pages 585 - 92
J. MICROBIOL BIOTECHNOL, vol. 22, no. 12, December 2012 (2012-12-01), pages 1714 - 23
ASANO, R. ET AL.: "Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody", J. BIOL. CHEM., vol. 285, no. 27, 2010, pages 20844 - 20849, XP055110416, DOI: 10.1074/jbc.M110.120444
NAT REV DRUG DISCOV, 7 June 2019 (2019-06-07)
PROC NATL ACAD SCI U S A., no. 14, 15 July 1993 (1993-07-15), pages 6444 - 8
SCI REP, vol. 7, no. 1, 6 June 2017 (2017-06-06), pages 2862
YASUYUKI TAKAGI: "Procedure for Experiment in Genetic Engineering", 1982, COLD SPRING HARBOR LABORATORY
"Molecular/Cloning", 1989, COLD SPRING HARBOR LABORATORY
"Methods in Enzymology", vol. 194, 1991
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, 1994
J. MICROBIOLOGY, 2012, pages 638 - 643
J. BACTERIOLOGY, 2005, pages 5799 - 5808
BIOTECHNOL. LETT., vol. 30, 2008, pages 1983 - 1988
BIOTECHNOL. LETT., vol. 28, 2006, pages 163 - 168
APPL ENVIRON MICROBIOL., vol. 200672, no. 11, pages 7401 - 7405
CANCER GENE THER, vol. 200714, pages 151 - 157
J MICROBIOL BIOTECHNOL, vol. 22, no. 12, December 2012 (2012-12-01), pages 1714 - 23
J MICROBIOL, vol. 50, no. 4, August 2012 (2012-08-01), pages 638 - 43
JMICROBIOL, vol. 50, no. 4, August 2012 (2012-08-01), pages 638 - 43
BIOSCI BIOTECHNOL BIOCHEM., vol. 69, no. 2, February 2005 (2005-02-01), pages 422 - 5
LETT APPL MICROBIOL, vol. ll, no. 4, October 1990 (1990-10-01), pages 220 - 3
J MICROBIOL BIOTECHNOL, vol. 19, no. 4, April 2009 (2009-04-01), pages 403 - 8
APPL ENVIRON MICROBIOL, vol. 73, no. 24, December 2007 (2007-12-01), pages 7858 - 66
PLASMID, vol. 57, no. 2, March 2007 (2007-03-01), pages 165 - 74
APPL ENVIRON MICROBIOL, vol. 72, no. 1, January 2006 (2006-01-01), pages 527 - 35
MICROBIOLOGY, vol. 145, March 1999 (1999-03-01), pages 585 - 92
J. MICROBIOL BIOTECHNOL, vol. 22, no. 12, December 2012 (2012-12-01), pages 1714 - 23
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
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