Title:
BIGLYCAN AND RELATED THERAPEUTICS AND METHODS OF USE
Document Type and Number:
WIPO Patent Application WO2003070195
Kind Code:
A3
Abstract:
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophin associated protein complex (DAPC); disorders associated with abnormal synapses or neuromuscular junctions, including those resulting from an abnormal MuSK activation or acetylcholine receptor (AChR) aggregation. Example of diseases include muscular dystrophies, such as Duchenne's Muscular Dystrophy, Becker's Muscular Dystrophy, neuromuscular disorders and neurological disorders.
Inventors:
FALLON JUSTIN R (US)
MCKECHNIE BETH (US)
RAFII MICHAEL (US)
CREELY HILLIARY (US)
BOWE MARK A (US)
FERRI RAYMOND (US)
MCKECHNIE BETH (US)
RAFII MICHAEL (US)
CREELY HILLIARY (US)
BOWE MARK A (US)
FERRI RAYMOND (US)
Application Number:
PCT/US2003/005418
Publication Date:
January 15, 2004
Filing Date:
February 19, 2003
Export Citation:
Assignee:
UNIV BROWN RES FOUND (US)
FALLON JUSTIN R (US)
MCKECHNIE BETH (US)
RAFII MICHAEL (US)
CREELY HILLIARY (US)
BOWE MARK A (US)
FERRI RAYMOND (US)
FALLON JUSTIN R (US)
MCKECHNIE BETH (US)
RAFII MICHAEL (US)
CREELY HILLIARY (US)
BOWE MARK A (US)
FERRI RAYMOND (US)
International Classes:
A61K38/17; G01N33/68; (IPC1-7): G01N33/48; A61K38/00; C07K1/00; C07K14/00; C07K17/00; G01N33/566; G01N33/567
Domestic Patent References:
| WO1993010808A1 | 1993-06-10 |
Foreign References:
| EP0686397A2 | 1995-12-13 | |||
| US5705609A | 1998-01-06 |
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