Title:
AMINO ACID AND PEPTIDE-MODIFIED FORMS OF GLUCOCORTICOIDS
Document Type and Number:
WIPO Patent Application WO2003070194
Kind Code:
A3
Abstract:
Amino acid corticosteroid esters which may function as pro-drugs, and formulations of the amino acid corticosteroid esters with a second active ingredient such as formoterol are disclosed. Composition of the invention include amino acid corticosteroid esters of Formula (I) that are used to make solution-stable pharmaceutical compositions or stable co-dispersions of pharmaceutical compositions in an aerosol formulation, or in a manual pump spray formulation containing one or more active ingredients. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.
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Inventors:
CURRIE MARK G (US)
GROVER PAUL (US)
JONES STEVE (US)
SENANAYAKE CHRIS H (US)
NIE XIAOYI (US)
GROVER PAUL (US)
JONES STEVE (US)
SENANAYAKE CHRIS H (US)
NIE XIAOYI (US)
Application Number:
PCT/US2003/005204
Publication Date:
December 04, 2003
Filing Date:
February 20, 2003
Export Citation:
Assignee:
SEPRACOR INC (US)
CURRIE MARK G (US)
GROVER PAUL (US)
JONES STEVE (US)
SENANAYAKE CHRIS H (US)
NIE XIAOYI (US)
CURRIE MARK G (US)
GROVER PAUL (US)
JONES STEVE (US)
SENANAYAKE CHRIS H (US)
NIE XIAOYI (US)
International Classes:
C07J41/00; C07J43/00; C07J71/00; A61K9/00; (IPC1-7): A61K9/12; A61K9/14; A61K38/00
Foreign References:
| US6136294A | 2000-10-24 | |||
| US5571791A | 1996-11-05 |
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