Title:
BINDING AGENTS: CHIMERIC LIGAND/RECEPTOR PROTEINS
Document Type and Number:
WIPO Patent Application WO2001096565
Kind Code:
A3
Abstract:
This invention relates to agents which bind to cell surface receptors; methods to manufacture said agents; therapeutic compositions comprising said agents; and screening methods to identify novel agents.
Inventors:
ROSS RICHARD (GB)
ARTYMIUK PETER (GB)
SAYERS JON (GB)
ARTYMIUK PETER (GB)
SAYERS JON (GB)
Application Number:
PCT/GB2001/002645
Publication Date:
August 01, 2002
Filing Date:
June 18, 2001
Export Citation:
Assignee:
ASTERION LTD (GB)
ROSS RICHARD (GB)
ARTYMIUK PETER (GB)
SAYERS JON (GB)
ROSS RICHARD (GB)
ARTYMIUK PETER (GB)
SAYERS JON (GB)
International Classes:
C12N15/09; A61K38/00; A61K38/21; A61K38/22; A61K38/27; A61P3/04; A61P3/06; A61P3/10; A61P5/06; A61P7/06; A61P9/12; A61P13/12; A61P19/02; A61P19/10; A61P29/00; A61P31/00; A61P35/00; A61P37/02; C07K14/475; C07K14/52; C07K14/54; C07K14/575; C07K14/61; C07K14/705; C07K14/715; C07K14/72; C07K19/00; C12N1/15; C12N1/21; C12N5/10; C12N15/12; C12N15/18; C12N15/24; C12P21/02; (IPC1-7): C12N15/12; A61K38/17; C07K14/54; C07K14/61; C07K14/715; C07K14/72; C12N15/18; C12N15/24; C12N15/62
Domestic Patent References:
| WO1997032891A2 | 1997-09-12 | |||
| WO1999002552A2 | 1999-01-21 | |||
| WO1986005804A1 | 1986-10-09 | |||
| WO1990005185A1 | 1990-05-17 | |||
| WO2000018932A2 | 2000-04-06 | |||
| WO1992021029A1 | 1992-11-26 |
Foreign References:
| US4857637A | 1989-08-15 | |||
| EP0950710A2 | 1999-10-20 | |||
| EP0741187A2 | 1996-11-06 |
Other References:
ROSS R J M ET AL: "A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein.", MOLECULAR ENDOCRINOLOGY, vol. 11, no. 3, 1997, pages 265 - 273, XP002181691, ISSN: 0888-8809
MORAN P ET AL: "A NONFUNCTIONAL SEQUENCE CONVERTED TO A SIGNAL FOR GLYCOPHOSPHATIDYLINOSITOL MEMBRANE ANCHOR ATTACHMENT", JOURNAL OF CELL BIOLOGY, vol. 115, no. 2, 1991, pages 329 - 336, XP001031102, ISSN: 0021-9525
YIYING ZHANG ET AL: "POSITIONAL CLONING OF THE MOUSE OBESE GENE AND ITS HUMAN HOMOLOGUE", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 372, no. 6505, 1 December 1994 (1994-12-01), pages 425 - 432, XP000602062, ISSN: 0028-0836
TARTAGLIA L A ET AL: "IDENTIFICATION AND EXPRESSION CLONING OF A LEPTIN RECEPTOR, OB-R", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 83, no. 7, 29 December 1995 (1995-12-29), pages 1263 - 1271, XP000602068, ISSN: 0092-8674
HIBI M ET AL: "MOLECULAR CLONING AND EXPRESSION OF AN IL-6 SIGNAL TRANSDUCER, GP130", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 63, 21 December 1990 (1990-12-21), pages 1149 - 1157, XP002931740, ISSN: 0092-8674
See also references of EP 1290170A2
MORAN P ET AL: "A NONFUNCTIONAL SEQUENCE CONVERTED TO A SIGNAL FOR GLYCOPHOSPHATIDYLINOSITOL MEMBRANE ANCHOR ATTACHMENT", JOURNAL OF CELL BIOLOGY, vol. 115, no. 2, 1991, pages 329 - 336, XP001031102, ISSN: 0021-9525
YIYING ZHANG ET AL: "POSITIONAL CLONING OF THE MOUSE OBESE GENE AND ITS HUMAN HOMOLOGUE", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 372, no. 6505, 1 December 1994 (1994-12-01), pages 425 - 432, XP000602062, ISSN: 0028-0836
TARTAGLIA L A ET AL: "IDENTIFICATION AND EXPRESSION CLONING OF A LEPTIN RECEPTOR, OB-R", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 83, no. 7, 29 December 1995 (1995-12-29), pages 1263 - 1271, XP000602068, ISSN: 0092-8674
HIBI M ET AL: "MOLECULAR CLONING AND EXPRESSION OF AN IL-6 SIGNAL TRANSDUCER, GP130", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 63, 21 December 1990 (1990-12-21), pages 1149 - 1157, XP002931740, ISSN: 0092-8674
See also references of EP 1290170A2
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