Title:
BIOCATALYST AND METHOD FOR THE SYNTHESIS OF UBROGEPANT INTERMEDIATES
Document Type and Number:
WIPO Patent Application WO/2023/169184
Kind Code:
A1
Abstract:
Provided are engineered transaminase polypeptides for the synthesis of Ubrogepant intermediates with high stereoselectivity, high catalytic activity and good stability. Also provided is a reaction process for the asymmetric synthesis of Ubrogepant intermediates using the transaminase polypeptide.
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Inventors:
CHEN HAIBIN (CN)
HU HU (CN)
CAI BAOQIN (CN)
XU JUNPENG (CN)
LIU SITONG (CN)
JIN LUPING (CN)
WU XINWEI (CN)
CUI QINYAN (CN)
ZHANG CHENGXIAO (CN)
ZHU KAILONG (CN)
HU HU (CN)
CAI BAOQIN (CN)
XU JUNPENG (CN)
LIU SITONG (CN)
JIN LUPING (CN)
WU XINWEI (CN)
CUI QINYAN (CN)
ZHANG CHENGXIAO (CN)
ZHU KAILONG (CN)
Application Number:
PCT/CN2023/076973
Publication Date:
September 14, 2023
Filing Date:
February 17, 2023
Export Citation:
Assignee:
ENZYMASTER NINGBO BIO ENG CO LTD (CN)
International Classes:
C12N9/10; C12N1/21; C12N15/54; C12N15/70; C12P17/00; C12R1/19
Domestic Patent References:
| WO2021202321A1 | 2021-10-07 |
Foreign References:
| CN112048485A | 2020-12-08 | |||
| CN111411096A | 2020-07-14 |
Other References:
DATABASE PROTEIN ANONYMOUS : "branched-chain amino acid aminotransferase, putative [Aspergillus fumigatus Af293]", XP093091361, retrieved from NCBI
NOBUYOSHI YASUDA, CLEATOR ED, KOSJEK BIRGIT, YIN JIANGUO, XIANG BANGPING, CHEN FRANK, KUO SHEN-CHUN, BELYK KEVIN, MULLENS PETER R.: "Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 21, no. 11, 19 October 2017 (2017-10-19), US , pages 1851 - 1858, XP055718660, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.7b00293
XINXING GAO, WEI PINGHE: "Advances in molecular modification of ω-transaminase", CHINESE JOURNAL OF BIOTECHNOLOGY, ZHONGGUO KEXUEYUAN WEISHENGWU YANJIUSUO, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF MICROBIOLOGY, CN, vol. 34, no. 7, 25 July 2018 (2018-07-25), CN , pages 1057 - 1068, XP055762590, ISSN: 1000-3061, DOI: 10.13345/j.cjb.170455
NOBUYOSHI YASUDA, CLEATOR ED, KOSJEK BIRGIT, YIN JIANGUO, XIANG BANGPING, CHEN FRANK, KUO SHEN-CHUN, BELYK KEVIN, MULLENS PETER R.: "Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant", ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMERICAN CHEMICAL SOCIETY, US, vol. 21, no. 11, 19 October 2017 (2017-10-19), US , pages 1851 - 1858, XP055718660, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.7b00293
XINXING GAO, WEI PINGHE: "Advances in molecular modification of ω-transaminase", CHINESE JOURNAL OF BIOTECHNOLOGY, ZHONGGUO KEXUEYUAN WEISHENGWU YANJIUSUO, CHINESE ACADEMY OF SCIENCES, INSTITUTE OF MICROBIOLOGY, CN, vol. 34, no. 7, 25 July 2018 (2018-07-25), CN , pages 1057 - 1068, XP055762590, ISSN: 1000-3061, DOI: 10.13345/j.cjb.170455
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