A BIOLOGICAL METHOD FOR THE PRODUCTION OF ALPHA-METHYLENE-GAMMA-BUTYROLACTONE AND ITS INTERMEDIATES

Title:

A BIOLOGICAL METHOD FOR THE PRODUCTION OF ALPHA-METHYLENE-GAMMA-BUTYROLACTONE AND ITS INTERMEDIATES

Document Type and Number:

WIPO Patent Application WO2002101013

Kind Code:

A3

Abstract:

This invention relates to genes encoding key enzymes in the biosynthesis of alpha-methylene-gamma-butyrolactone (tulipalin A). The key enzymes are glutamate decarboxylase, gamma-aminobutyrate aminotransferase, gamma-hydroxybutyrate dehydrogenase and UDP-glucosyltransferase. The genes and their expression products are useful for the creation of recombinant organisms that have the ability to synthesize tulipalin A, tuliposide A or any tuliposide A pathway intermediates.

Inventors:

DAMUDE HOWARD GLENN (US)
FLINT DENNIS (US)
PRABHU VIKRAM (US)
WANG HONG (US)

Application Number:

PCT/US2002/018230

Publication Date:

February 17, 2005

Filing Date:

June 10, 2002

Export Citation:

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Assignee:

DU PONT (US)
DAMUDE HOWARD GLENN (US)
FLINT DENNIS (US)
PRABHU VIKRAM (US)
WANG HONG (US)

International Classes:

C12N1/21; C12N15/52; C12P7/42; C12P13/00; C12P17/04; C12P19/44; C12P21/04; (IPC1-7): C12N9/88; C07H21/04; C12N1/20; C12N5/00; C12N15/00; C12P21/04; C12Q1/00; C12Q1/68

Other References:

BAUM G.: "A plant glutamate decarboxylase containing a calmodulin binding domain. Cloning, sequence, and functional analysis", J. BIOL. CHEM., vol. 268, no. 26, September 1993 (1993-09-01), pages 19610 - 19617, XP002983830
DATABASE GENABNK [online] June 1998 (1998-06-01), YUN S.J., OH S.H.: "Cloning and characterization of a tobacco cDNA encoding calcium/calmodulin-dependent glutamate decarboxylase", XP002983831, accession no. NCBI Database accession no. (AF020425)

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